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Completed

NCT Number: NCT02341365

Vitamin D Influence on Oocyte Donation

Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.

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Key information

Conditions

Disorder of Phosphate, Calcium and Vitamin D Metabolism Female Infertility Due to Diminished Ovarian Reserve Hormonal Requirement Reproductive Disorder

Age range

18 year–34 year

Sex eligibility

Female

Study type

Observational

About this study

Design: Retrospective study. Setting: University affiliated private IVF center. Intervention: Serum analysis of vitamin D, bioavailable vitamin D, antimullerian hormone (AMH), antral follicular count (AFC), reproductive outcome of oocytes recipients Main outcome measure: AMH, AFC, number of oocytes retrieved and number of mature oocytes, pregnancy and implantation rate of donated oocytes'recipients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Caucasian race,
  • between 18 and 34 years of age,
  • all donors had normal menstrual cycles of 26-34 days,
  • normal weight range (BMI 18- 25 Kg/m2),
  • normal uterus and ovaries on transvaginal ultrasound (no signs of polycystic ovarian syndrome), and
  • an antral follicle count (AFC) >10,
  • normal karyotype

Exclusion criteria

  • current or past exposure to radiation or hazardous chemical substances,
  • history of drug use,
  • family history of hereditary chromosomal diseases,
  • sexually transmitted diseases

Treatment and study plan

vitamin D,AMH, AFC, reproductive outcome egg recipients

Other

observational study of 269 donnors

Primary outcomes

  1. Numbers of oocytes retrieved

    Time frame: 2 months

Secondary outcomes

  1. implantation rate

    Time frame: 2 months

  2. pregnancy rate

    Time frame: 2 months

  3. AFC

    Time frame: 2 months

  4. number of mature oocytes

    Time frame: 2 months

  5. AMH

    Time frame: 2 months

Sponsors and collaborators

Lead sponsor

IVI Madrid

Other

Registry information

Official study title

Impact of Vitamin D Levels on Ovarian Reserve and Ovarian Response to Controlled Stimulation in Egg Donors

Important dates

Study start
2013
Primary completion
2014
Study completion
2015
First posted
Jan 19, 2015
Registry last updated
Jan 19, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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