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Completed

NCT Number: NCT05779410

Vitamin D in Healthy Adults After Strenuous Endurance Exercise

The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).

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Key information

Conditions

Healthy

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Taipei Medical University

Taipei, 110, Taiwan

About this study

All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The volunteers included have conditions as stated below :
  • no history of cardiovascular, liver, kidney and diabetes disease
  • no acute sport injury
  • male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min
  • did not participated in any clinical trials or research in the last 3 months before our experiment
  • no supplements were taken during the experimental period
  • were requested to maintain their regular daily life style and avoid alcohol intake

Exclusion criteria

  • The volunteers were excluded if they have the situation stated below:
  • history of cardiovascular, liver, kidney and diabetes disease
  • acute sport injury
  • their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/min
  • participated in any clinical trials or experimental research in the last 3 months before our experiment
  • taking supplement during the experimental period
  • did not maintain their regular eating habit or drink alcohol

Treatment and study plan

Vitamin D

Dietary Supplement

Participants received 5,000 IU of vitamin D orally twice daily for 4 weeks

Other names: Liquid Shield Vitamin D3+E

Medium-chain triglycerides

Dietary Supplement

Participants received the same amount of placebo matching vitamin D orally twice daily for 4 weeks

Primary outcomes

  1. Concentration of Neutrophil

    Time frame: before exercise

  2. Concentration ofNeutrophil

    Time frame: immediately after exercise

  3. Concentration of Neutrophil

    Time frame: 2-hour after exercise

  4. Concentration of Neutrophil

    Time frame: 4-hour after exercise

  5. Concentration of Neutrophil

    Time frame: 8-hour after exercise

  6. Concentration of Neutrophil

    Time frame: 24-hour after exercise

  7. Concentration of eosinophil

    Time frame: before exercise

  8. Concentration of eosinophil

    Time frame: immediately after exercise

  9. Concentration of eosinophil

    Time frame: 2-hour after exercise

  10. Concentration of eosinophil

    Time frame: 4-hour after exercise

  11. Concentration of eosinophil

    Time frame: 8-hour after exercise

  12. Concentration of eosinophil

    Time frame: 24-hour after exercise

  13. Concentration of basophil

    Time frame: before exercise

  14. Concentration of basophil

    Time frame: immediately after exercise

  15. Concentration of basophil

    Time frame: 2-hour after exercise

  16. Concentration of basophil

    Time frame: 4-hour after exercise

  17. Concentration of basophil

    Time frame: 8-hour after exercise

  18. Concentration of basophil

    Time frame: 24-hour after exercise

  19. Concentration of monocyte

    Time frame: before exercise

  20. Concentration of monocyte

    Time frame: immediately after exercise

  21. Concentration of monocyte

    Time frame: 2-hour after exercise

  22. Concentration of monocyte

    Time frame: 4-hour after exercise

  23. Concentration of monocyte

    Time frame: 8-hour after exercise

  24. Concentration of monocyte

    Time frame: 24-hour after exercise

  25. Concentration of lymphocyte

    Time frame: before exercise

  26. Concentration of lymphocyte

    Time frame: immediately after exercise

  27. Concentration of lymphocyte

    Time frame: 2-hour after exercise

  28. Concentration of lymphocyte

    Time frame: 4-hour after exercise

  29. Concentration of lymphocyte

    Time frame: 8-hour after exercise

  30. Concentration of lymphocyte

    Time frame: 24-hour after exercise

  31. Concentration of CD4+

    Time frame: before exercise

  32. Concentration of CD4+

    Time frame: immediately after exercise

  33. Concentration of CD4+

    Time frame: 2-hour after exercise

  34. Concentration of CD4+

    Time frame: 4-hour after exercise

  35. Concentration of CD4+

    Time frame: 8-hour after exercise

  36. Concentration of CD4+

    Time frame: 24-hour after exercise

  37. Concentration of CD8+

    Time frame: before exercise

  38. Concentration of CD8+

    Time frame: immediately after exercise

  39. Concentration of CD8+

    Time frame: 2-hour after exercise

  40. Concentration of CD8+

    Time frame: 4-hour after exercise

  41. Concentration of CD8+

    Time frame: 8-hour after exercise

  42. Concentration of CD8+

    Time frame: 24-hour after exercise

  43. Concentration of CD19+

    Time frame: before exercise

  44. Concentration of CD19+

    Time frame: immediately after exercise

  45. Concentration of CD19+

    Time frame: 2-hour after exercise

  46. Concentration of CD19+

    Time frame: 4-hour after exercise

  47. Concentration of CD19+

    Time frame: 8-hour after exercise

  48. Concentration of CD19+

    Time frame: 24-hour after exercise

  49. Concentration of CD56+

    Time frame: before exercise

  50. Concentration of CD56+

    Time frame: immediately after exercise

  51. Concentration of CD56+

    Time frame: 2-hour after exercise

  52. Concentration of CD56+

    Time frame: 4-hour after exercise

  53. Concentration of CD56+

    Time frame: 8-hour after exercise

  54. Concentration of CD56+

    Time frame: 24-hour after exercise

  55. Concentration of IgA

    Time frame: before exercise

  56. Concentration of IgA

    Time frame: immediately after exercise

  57. Concentration of IgA

    Time frame: 2-hour after exercise

  58. Concentration of IgA

    Time frame: 4-hour after exercise

  59. Concentration of IgA

    Time frame: 8-hour after exercise

  60. Concentration of IgA

    Time frame: 24-hour after exercise

  61. Concentration of Cathelicidin

    Time frame: before exercise

  62. Concentration of Cathelicidin

    Time frame: immediately after exercise

  63. Concentration of Cathelicidin

    Time frame: 2-hour after exercise

  64. Concentration of Cathelicidin

    Time frame: 4-hour after exercise

  65. Concentration of Cathelicidin

    Time frame: 8-hour after exercise

  66. Concentration of Cathelicidin

    Time frame: 24-hour after exercise

  67. Concentration of TNF-α

    Time frame: before exercise

  68. Concentration of TNF-α

    Time frame: immediately after exercise

  69. Concentration of TNF-α

    Time frame: 2-hour after exercise

  70. Concentration of TNF-α

    Time frame: 4-hour after exercise

  71. Concentration of TNF-α

    Time frame: 8-hour after exercise

  72. Concentration of TNF-α

    Time frame: 24-hour after exercise

  73. Concentration of IL-1β

    Time frame: before exercise

  74. Concentration of IL-1β

    Time frame: immediately after exercise

  75. Concentration of IL-1β

    Time frame: 2-hour after exercise

  76. Concentration of IL-1β

    Time frame: 4-hour after exercise

  77. Concentration of IL-1β

    Time frame: 8-hour after exercise

  78. Concentration of IL-1β

    Time frame: 24-hour after exercise

  79. Concentration of IFN-γ

    Time frame: before exercise

  80. Concentration of IFN-γ

    Time frame: immediately after exercise

  81. Concentration of IFN-γ

    Time frame: 2-hour after exercise

  82. Concentration of IFN-γ

    Time frame: 4-hour after exercise

  83. Concentration of IFN-γ

    Time frame: 8-hour after exercise

  84. Concentration of IFN-γ

    Time frame: 24-hour after exercise

  85. Concentration of IL-2

    Time frame: before exercise

  86. Concentration of IL-2

    Time frame: immediately after exercise

  87. Concentration of IL-2

    Time frame: 2-hour after exercise

  88. Concentration of IL-2

    Time frame: 4-hour after exercise

  89. Concentration of IL-2

    Time frame: 8-hour after exercise

  90. Concentration of IL-2

    Time frame: 24-hour after exercise

  91. Concentration of IL-4

    Time frame: before exercise

  92. Concentration of IL-4

    Time frame: immediately after exercise

  93. Concentration of IL-4

    Time frame: 2-hour after exercise

  94. Concentration of IL-4

    Time frame: 4-hour after exercise

  95. Concentration of IL-4

    Time frame: 8-hour after exercise

  96. Concentration of IL-4

    Time frame: 24-hour after exercise

  97. Concentration of IL-8

    Time frame: before exercise

  98. Concentration of IL-8

    Time frame: immediately after exercise

  99. Concentration of IL-8

    Time frame: 2-hour after exercise

  100. Concentration of IL-8

    Time frame: 4-hour after exercise

  101. Concentration of IL-8

    Time frame: 8-hour after exercise

  102. Concentration of IL-8

    Time frame: 24-hour after exercise

  103. Concentration of IL-10

    Time frame: before exercise

  104. Concentration of IL-10

    Time frame: immediately after exercise

  105. Concentration of IL-10

    Time frame: 2-hour after exercise

  106. Concentration of IL-10

    Time frame: 4-hour after exercise

  107. Concentration of IL-10

    Time frame: 8-hour after exercise

  108. Concentration of IL-10

    Time frame: 24-hour after exercise

  109. Concentration of TBARS

    Time frame: before exercise

  110. Concentration of TBARS

    Time frame: immediately after exercise

  111. Concentration of TBARS

    Time frame: 2-hour after exercise

  112. Concentration of TBARS

    Time frame: 4-hour after exercise

  113. Concentration of TBARS

    Time frame: 8-hour after exercise

  114. Concentration of TBARS

    Time frame: 24-hour after exercise

  115. Concentration of PC

    Time frame: before exercise

  116. Concentration of PC

    Time frame: immediately after exercise

  117. Concentration of PC

    Time frame: 2-hour after exercise

  118. Concentration of PC

    Time frame: 4-hour after exercise

  119. Concentration of PC

    Time frame: 8-hour after exercise

  120. Concentration of PC

    Time frame: 24-hour after exercise

  121. Concentration of SOD

    Time frame: before exercise

  122. Concentration of SOD

    Time frame: immediately after exercise

  123. Concentration of SOD

    Time frame: 2-hour after exercise

  124. Concentration of SOD

    Time frame: 4-hour after exercise

  125. Concentration of SOD

    Time frame: 8-hour after exercise

  126. Concentration of SOD

    Time frame: 24-hour after exercise

  127. Concentration of catalase

    Time frame: before exercise

  128. Concentration of catalase

    Time frame: immediately after exercise

  129. Concentration of catalase

    Time frame: 2-hour after exercise

  130. Concentration of catalase

    Time frame: 4-hour after exercise

  131. Concentration of catalase

    Time frame: 8-hour after exercise

  132. Concentration of catalase

    Time frame: 24-hour after exercise

  133. Concentration of GPx

    Time frame: before exercise

  134. Concentration of GPx

    Time frame: immediately after exercise

  135. Concentration of GPx

    Time frame: 2-hour after exercise

  136. Concentration of GPx

    Time frame: 4-hour after exercise

  137. Concentration of GPx

    Time frame: 8-hour after exercise

  138. Concentration of GPx

    Time frame: 24-hour after exercise

  139. Concentration of CK

    Time frame: before exercise

  140. Concentration of CK

    Time frame: immediately after exercise

  141. Concentration of CK

    Time frame: 2-hour after exercise

  142. Concentration of CK

    Time frame: 4-hour after exercise

  143. Concentration of CK

    Time frame: 8-hour after exercise

  144. Concentration of CK

    Time frame: 24-hour after exercise

  145. Concentration of LDH

    Time frame: before exercise

  146. Concentration of LDH

    Time frame: immediately after exercise

  147. Concentration of LDH

    Time frame: 2-hour after exercise

  148. Concentration of LDH

    Time frame: 4-hour after exercise

  149. Concentration of LDH

    Time frame: 8-hour after exercise

  150. Concentration of LDH

    Time frame: 24-hour after exercise

  151. Concentration of IL-6

    Time frame: before exercise

  152. Concentration of IL-6

    Time frame: immediately after exercise

  153. Concentration of IL-6

    Time frame: 2-hour after exercise

  154. Concentration of IL-6

    Time frame: 4-hour after exercise

  155. Concentration of IL-6

    Time frame: 8-hour after exercise

  156. Concentration of IL-6

    Time frame: 24-hour after exercise

  157. Concentration of CRP

    Time frame: before exercise

  158. Concentration of CRP

    Time frame: immediately after exercise

  159. Concentration of CRP

    Time frame: 2-hour after exercise

  160. Concentration of CRP

    Time frame: 4-hour after exercise

  161. Concentration of CRP

    Time frame: 8-hour after exercise

  162. Concentration of CRP

    Time frame: 24-hour after exercise

Sponsors and collaborators

Lead sponsor

Taipei Medical University

Other

Collaborators

  • Panion & BF Biotech Inc.

Registry information

Official study title

Effects of Vitamin D Supplementation on Biochemical Responses and Aerobic Capacity After Strenuous Endurance Exercise

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Mar 22, 2023
Registry last updated
Mar 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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