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OpenTrials
Completed

NCT Number: NCT03088488

Vitamin D and Periodontitis

Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).

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Key information

Age range

25 year–45 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Inclusion Criteria:
  • never-smokers
  • no history of systemic disease
  • no patients had been under periodontal therapy and medicine for at least 6 months before the study
  • no pregnancy or lactation
  • no alcohol or antioxidant vitamin consumption.
  • Exclusion Criteria:
  • -

Treatment and study plan

fasting venous blood samples

Diagnostic Test

Primary outcomes

  1. Biochemical parameters

    Time frame: Baseline

    serum TNF-α

  2. Biochemical parameters

    Time frame: Baseline

    serum CTx

  3. Biochemical parameters

    Time frame: Baseline

    serum RANKL

  4. Biochemical parameters

    Time frame: Baseline

    serum OPG

  5. Biochemical parameters

    Time frame: Baseline

    serum 25-OH vitamin D

Secondary outcomes

  1. Periodontal parameters

    Time frame: Baseline

    The plaque index (PI)

  2. Periodontal parameters

    Time frame: Baseline

    gingival index (GI)

  3. Periodontal parameters

    Time frame: Baseline

    probing depth (PD)

  4. Periodontal parameters

    Time frame: Baseline

    clinical attachment level (CAL)

Sponsors and collaborators

Lead sponsor

Ordu University

Other

Registry information

Official study title

Relationship of Bone Metabolism Biomarkers and Serum 25-Hydroxy Vitamin D in Patients With Chronic Periodontitis

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Mar 23, 2017
Registry last updated
Mar 23, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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