NCT Number: NCT03088488
Vitamin D and Periodontitis
Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).
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Notify MeKey information
Conditions
Age range
25 year–45 year
Sex eligibility
All sexes
Study type
Observational
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
- Inclusion Criteria:
- never-smokers
- no history of systemic disease
- no patients had been under periodontal therapy and medicine for at least 6 months before the study
- no pregnancy or lactation
- no alcohol or antioxidant vitamin consumption.
- Exclusion Criteria:
- -
Treatment and study plan
Primary outcomes
-
Biochemical parameters
Time frame: Baseline
serum TNF-α
-
Biochemical parameters
Time frame: Baseline
serum CTx
-
Biochemical parameters
Time frame: Baseline
serum RANKL
-
Biochemical parameters
Time frame: Baseline
serum OPG
-
Biochemical parameters
Time frame: Baseline
serum 25-OH vitamin D
Secondary outcomes
-
Periodontal parameters
Time frame: Baseline
The plaque index (PI)
-
Periodontal parameters
Time frame: Baseline
gingival index (GI)
-
Periodontal parameters
Time frame: Baseline
probing depth (PD)
-
Periodontal parameters
Time frame: Baseline
clinical attachment level (CAL)
Sponsors and collaborators
Lead sponsor
Ordu University
Other
Registry information
Official study title
Relationship of Bone Metabolism Biomarkers and Serum 25-Hydroxy Vitamin D in Patients With Chronic Periodontitis
Important dates
- Study start
- 2015
- Primary completion
- 2016
- Study completion
- 2016
- First posted
- Mar 23, 2017
- Registry last updated
- Mar 23, 2017
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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