Vitamin D and Hypertensive Disorders of Pregnancy

The purpose of this study is to further investigate the association between vitamin D deficiency/insufficiency and hypertensive disorders of pregnancy by studying the impact of screening for vitamin D deficiency and supplementation when low levels of vitamin D are detected. Screening for vitamin D deficiency (less than 20 ng/mL) and insufficiency (less than 30 ng/mL) may determine the need for additional supplementation, as most prenatal vitamins only contain 400 IU of vitamin D. The rates of hypertensive disorders of pregnancy amongst patients who received supplementation and maintained adequate vitamin D levels will be followed.

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Key information

Conditions

Hypertensive Disorders of Pregnancy

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Pregnant women
18-45 years old
Receiving care at outpatient OB office of TriHealth's Women's Services Comprehensive OB-GYN Team with a plan to deliver at Bethesda North Hospital

Exclusion criteria

Non-English speaking
Unable to provide consent to research study participation
Diagnosis of preexisting renal disease
Diagnoses of preexisting chronic hypertension
Diagnosis of cardiovascular diseases
Diagnosis of conditions limiting fat absorption
Diagnosis of sarcoidosis

Treatment and study plan

Vitamin D Levels measurement

Diagnostic Test

Patient will have a vitamin D level drawn with their other prenatal labs during an OB visit. If vitamin D insufficiency (less than 30 ng/mL) or deficiency (less than 20 ng/mL) is detected, the patient will be prescribed and provided a supplementation of 2000 IU of vitamin D daily for the remainder of the pregnancy.

Primary outcomes

Hypertensive disorders of pregnancy

Time frame: During pregnancy, up to 9 months

Was patient diagnosed with a hypertensive disorder of pregnancy (preeclampsia or GHTN) per clinician judgement based on ACOG guidelines

Study contacts

Contact information is provided by the study sponsor or research team.

Rachel B Baker

CONTACT

[email protected]

513-569-6191

Sponsors and collaborators

Lead sponsor

TriHealth Inc.

Other

Registry information

Official study title

The Relationship Among Vitamin Deficiency/Insufficiency, Vitamin Supplementation, and Hypertensive Disorders of Pregnancy

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Jun 12, 2025
Registry last updated: Jun 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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