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OpenTrials
Completed

NCT Number: NCT05498337

Vital Pulp Therapy With Different Materials for Young Permanent Teeth

This study will be conducted to:

Evaluate clinically and radiographically apexogenesis in immature permanent molars using:

1. Calcium Hydroxide. 2. MTA. 3. Laser. 4. Laser combined with MTA.

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Key information

Conditions

Vital Pulp Therapy

Age range

7 year–9 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mansoura University

Al Mansurah, Dakhalia Governrate, 35516, Egypt

About this study

Calcium Hydroxide has been the most commonly utilized pulpotomy agent for vital pulp therapy. It is the earliest medicament employed in pulpotomy that possesses the ability to stimulate tertiary dentinogenesis. This is attributed to its high alkalinity after mixing with water. Calcium hydroxide has a high pH, and its dental use relates chiefly to its ability to stimulate mineralization and also to its antibacterial property.

Biocompatibility and sealing ability are the most important properties, which account for optimal healing response in vital pulp therapy. Unlike conventional materials, MTA has low solubility and maintains its physical integrity after placement. It has several desirable characteristics in terms of biocompatibility, bioactivity, hydrophilicity, radiopacity, sealing ability and low solubility.

Diode laser in a young permanent tooth with traumatically exposed pulp has proved to be an effective technique for Pulpotomy in an immature tooth. Therefore, the use of soft-tissue diode lasers can influence the treatment outcome and should be seen as a predicable tool for vital pulp therapy.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Medically free
  • Vital teeth

Exclusion criteria

  • Medically compromised
  • Chronic abscess
  • Non-vital teeth

Treatment and study plan

Calcium hydroxide

Other

Dental pulp medicament material

MTA

Other

Dental pulp medicament material

Diode laser

Device

Device used in pulp therapy

Primary outcomes

  1. Root completion

    Time frame: one year

    Closure of radiographic apex using Scanora 5.2.6 digital software

Secondary outcomes

  1. Root lengthening and thickening

    Time frame: one year

    Measuring the increase in length and width of the root canals using Scanora 5.2.6 digital software

Other outcomes

  1. Clinical evaluation

    Time frame: one year

    Absence of pain and tenderness to percussion using facial scale

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Clinical Evaluation of Different Treatment Modalities for Vital Pulp of Immature Permanent Molars

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Aug 12, 2022
Registry last updated
Oct 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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