Skip to main content
OpenTrials
Completed

NCT Number: NCT00435058

Visual Function Changes After Intraocular Pressure Reduction

During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure reduction. This study aims at evaluating the correlation between intraocular pressure reduction and visual function changes in glaucoma patients after using antiglaucoma medications.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Glaucoma Eye Diseases Ocular Hypertension

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Primary open angle glaucoma patients without use of antiglaucoma medications will be enrolled in this study. After inclusion, the patients will randomly receive one of three antiglaucoma medications (timolol maleate 0,5%, brimonidine tartrate 0,2% or travoprost 0,004%) in one randomly selected eye.

The patients will be evaluated with Goldmann applanation tonometry, visual acuity test, contrast sensitivity test, visual quality perception test (visual analogue scale) and standard automated perimetry before and after 4 weeks of glaucoma treatment onset.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Primary open angle glaucoma
  • Intraocular pressure greater than 21 mmHg

Exclusion criteria

  • Best corrected visual acuity (BCVA) worse than 20/80
  • Significant media opacity
  • History of steroid use

Treatment and study plan

timolol maleate 0,5%

Drug

brimonidine tartrate 0,2%

Drug

travoprost 0,004%

Drug

Primary outcomes

  1. intraocular pressure

  2. contrast sensitivity

  3. visual quality perception

Secondary outcomes

  1. Mean deviation of the visual field (MD)

  2. Pattern Standard Deviation of the visual field (PSD)

  3. visual acuity

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Visual Function Changes After Intraocular Pressure Reduction Using Antiglaucoma Medications: A Randomized Clinical Trial

Important dates

Study start
2005
Study completion
2006
First posted
Feb 14, 2007
Registry last updated
Feb 19, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.