Fondation Adolphe de Rothschild
Paris, PARIS, 75019, France
Location status: Recruiting
Recruiting
NCT Number: NCT04648124
VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies
The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.
Recruiting
Interested in participating?
Request InfoKey information
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patient over 18 years old
- Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique
- Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months
- Express consent to participate in the study
- Affiliate or beneficiary of a social security scheme
Exclusion criteria
- Patient benefiting from a legal protection measure
- Pregnant or breastfeeding woman
- Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).
- Other additional ocular pathology that can significantly affect vision
- Recent eye surgery less than 3 months old
Treatment and study plan
IRMf-r (séquence resting state)
DeviceFunctional MRI of functional brain networks
Primary outcomes
-
Localization and characterization of neural networks
Time frame: baseline
neuronal networks description using rest and morphological functionnal MRIs
-
Evolution of neuronal networks after retinal implantation
Time frame: baseline
neuronal networks description using rest and morphological functionnal MRIs
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Network
Registry information
Acronym: VICTOIRE
Important dates
- Study start
- 2021
- Primary completion
- 2026
- Study completion
- 2028
- First posted
- Dec 1, 2020
- Registry last updated
- Jan 5, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.