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OpenTrials
Completed

NCT Number: NCT03741621

Viscosity of Fibre Predicts Cholesterol-lowering in Healthy Individuals

To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals

Completed

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Key information

Conditions

Lipidemia Dyslipidemias Healthy Hyperlipidemias Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-healthy individuals

Exclusion criteria

  • regular alcohol consumption
  • regular smoking

Treatment and study plan

Viscous Fibre Blend

Dietary Supplement

High viscosity viscous fiber blend sprinkled on wheat and maize bran cereals(Bran Buds®; Kellogg Company)

Psyllium

Dietary Supplement

Bran Buds cereal (white bran and maize bran) with psyllium (Bran Buds® with PSY; Kellogg Company)

Wheat Bran

Dietary Supplement

All Bran cereal (All Bran®; Kellogg Company)

Primary outcomes

  1. change in LDL cholesterol

    Time frame: change from baseline after 21 days, relative to control

Secondary outcomes

  1. change in total cholesterol

    Time frame: change from baseline after 21 days, relative to control

  2. change in triglycerides

    Time frame: change from baseline after 21 days, relative to control

  3. change in HDL cholesterol

    Time frame: change from baseline after 21 days, relative to control

  4. change in apolipoprotein B

    Time frame: change from baseline after 21 days, relative to control

  5. change in apolipoprotein A-1

    Time frame: change from baseline after 21 days, relative to control

Sponsors and collaborators

Lead sponsor

Unity Health Toronto

Other

Collaborators

  • Kellogg Company
  • University of Toronto

Registry information

Official study title

Viscosity Rather Than Quality of Dietary Fibre Predicts Cholesterol-lowering Effect in Healthy Individuals

Important dates

Study start
1992
Primary completion
1994
Study completion
2010
First posted
Nov 15, 2018
Registry last updated
Nov 15, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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