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Completed

NCT Number: NCT06580353

Viscoelastic Properties of Respiratory and Peripheral Muscles of COPD Patients

The aim of this study was to compare the viscoelastic properties of auxiliary respiratory muscles and peripheral muscles of chronic obstructive pulmonary disease patients with healthy subjects. Myotonometry was used to evaluate the viscoelastic properties of the muscles. The viscoelastic properties of the sternoclaidus mastoid, pectoralis major, upper trapezius, deltoid, biceps brachii, rectus femoris, gastrocinemius, and tibialis anterior muscles were evaluated.

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Muscle Tone Abnormalities Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year and older

Sex eligibility

Male

Study type

Observational

Primary location

Gaziantep İslamic Science and Technology University

Gaziantep, Şahinbey, 27000, Turkey (Türkiye)

About this study

muscle viscoelastic properties; muscle tone, stiffness and elasticity. These features may vary due to muscle overuse, lack of relaxation and recovery. The aim is to investigate these differences in COPD patients and healthy individuals.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male gender,
  • body mass index (BMI) between 18.5-29.9 kg/m2,
  • stable COPD patients

Exclusion criteria

  • being in the acute exacerbation period for COPD patients,
  • having undergone any neurological, orthopaedic or thoracic surgery,
  • presence of malignancy in any organ,
  • presence of comorbidities affecting muscle atrophy (myasthenia gravis, muscular dystrophy, etc.).

Treatment and study plan

Primary outcomes

  1. Respiratory functions (PEF)

    Time frame: 1 Day

    Peak expiratory flow (PEF) were measured was evaluated with spirometry. It will be recorded as liters and expected percentage

  2. The Medical Research Council Scale

    Time frame: 1 Day

    Patients simply indicate on the scale the level of activity that causes dyspnoea in them according to the activities between 0-4.

  3. The COPD Assessment Test

    Time frame: 1 Day

    This statement describes a scale consisting of eight items, each with response values ranging from 0 to 5. The total score is calculated by summing the responses to all the items, resulting in a range from 0 to 40. A higher total score indicates a greater negative impact of the disease on the individual's quality of life and daily activities.

  4. Viscoelastic properties of muscles

    Time frame: 1 Day

    The viscoelastic properties of the muscles (muscle tone (Hz), and elasticity (Relative), stiffness (N/m)) were measured using a hand-held myotonometer.

  5. Respiratory functions (FEV1)

    Time frame: 1 Day

    In pulmonary function test was evaluated with spirometry. forced expiratory volume in the first second (FEV1);will be recorded as liters and expected percentage

  6. Respiratory functions (FVC)

    Time frame: 1 Day

    In pulmonary function test was evaluated with spirometry. forced expiratory volume in the first second (FEV1);will be recorded as liters and expected percentage

  7. Respiratory functions (FEV1/FVC)

    Time frame: 1 Day

    ratio of forced expiratory volume in the first second to vital capacity (FEV1/FVC) was evaluated with spirometry.

Sponsors and collaborators

Lead sponsor

Gaziantep Islam Science and Technology University

Other

Registry information

Official study title

Comparison of Viscoelastic Properties of Respiratory Muscles and Peripheral Muscles in Chronic Obstructive Pulmonary Disease Patients With Healthy Subjects

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Aug 30, 2024
Registry last updated
Nov 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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