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OpenTrials
Completed

NCT Number: NCT05332964

Virtual Reliability System for Visual Spatial Attention Evaluation in Stroke Patients

The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. The study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left each) and 100 age-matched healthy controls. The participants will conduct a simple reaction time task in VR, with stimuli designated in the left or right hemi-field. The stroke patients will also received traditional tests for hemi-neglect. Test-retest reliability of the assessment will be conducted in a subset of the control group. The stroke patients will be followed in 3-4 weeks.

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Key information

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital

Taipei, Taiwan

About this study

The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. The study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left hemisphere each) and 100 age-matched healthy controls. The participants will conduct a simple reaction time task in VR, with stimuli designated in the left or right hemi-field. The stroke patients will also receive traditional tests for hemi-neglect. The researchers will also collect the demographic data, cognition function and daily activity function. Test-retest reliability of the assessment will be conducted in a subset of the control group. The stroke patients will be followed in 3-4 weeks. The researchers will compare the results of a traditional hemi-neglect tests and VR-based tests and their changes in two occasions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for stroke patients:

  • aged at least 20 years old
  • diagnosed with stroke involving unilateral MCA and ACA territory
  • with unilateral upper limb with normal function
  • neurologically and medically stable.

Inclusion criteria

for control group:

  • healthy adults, age-matched to stroke patients

Exclusion criteria

for both groups:

  • with history of neurological or psychiatric conditions other than stroke;
  • significant cognitive or speech problems that cause difficulties to cooperate with testing;
  • significant visual problems (such as color blindness, visual loss, cataract, glaucoma or other major eye condition)
  • upper limb musculoskeletal disorders to cause difficulties to use the keyboard or controller;
  • history of seizure, vestibular dysfunction or vertigo
  • can't tolerate HMD-VR

Treatment and study plan

Primary outcomes

  1. reaction time

    Time frame: 4 weeks

    reaction time to the stimuli presented in the right or left hemi-field with VR software

  2. hemineglect tests

    Time frame: 4 weeks

    Paper-based behavior inattention test (BIT)

Secondary outcomes

  1. ADL

    Time frame: 4 weeks

    activities of daily living function evaluated by barthel index

  2. cognition

    Time frame: 4 weeks

    using Montreal Cognitive Assessment (MoCA)

  3. cybersickness

    Time frame: 1 day

    using Simulator Sickness Questionnaire (SSQ)

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Application of a Virtual Reliability System in the Evaluation of the Visual Spatial Attention in Stroke Patients

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 18, 2022
Registry last updated
Feb 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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