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NCT Number: NCT04804202

Virtual Cycling Environments for Persons With Parkinson Disease

This study asks three questions about Persons with Parkinson Disease that use a bicycle for exercise. 1. Does the use of virtual reality increase the intensity and and enjoyment of the experience compared to bicycling without virtual reality? 2. Does the way in which the bicycling (interval compared to continous) is performed affect the experience? 3. How does the way the virtual reality is delivered (with goggles or projected on a screen) affect the experience?

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Key information

Age range

45 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Health Professions, Newark, New Jersey, United States

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About this study

Participants attend two sessions. They complete movement assessments and questionnaires about physical activity. During the first session they bicycle in a semi-immersive (projected on a screen) and an immersive (with googles) virtual environment. After each bout they completed a questionnaire about the experience. In the second session they bicycle four times with and without a virtual environment using both a continous and interval mode. Their oxygen consumption is measured during cycling. They complete questionnaires after each exercise bout.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of Parkinson's disease
  • Hoehn and Yahr stages II-III,
  • 45-75 years old
  • able to ride a stationary upright bicycle
  • able to sign informed consent.

Exclusion criteria

  • Have a recent history of severe heart disease, severe lung disease, uncontrolled diabetes, traumatic brain injury or neurological disorder other than Parkinson Disease.
  • Are unable to follow directions or sign a consent form
  • Do not have adequate vision or hearing ability to see or hear a television
  • Have unstable medical condition or musculoskeletal disorder such as severe arthritis, recent knee surgery, hip surgery, or any other condition that the investigators determine would impair the ability to ride the bicycle
  • Have any other medical condition that prevents bicycling
  • Have moderate depression

Treatment and study plan

Bicycling with and without virtual reality

Other

In one session: Exercise intensity and enjoyment are measured while participants bicycle in a virtual compared to non-virtual environment. Cycling takes places in two modes continous and interval. In a second session exercise intensity and enjoyment are compared during bicycling with virtual reality presented in two different ways.

Primary outcomes

  1. Neuromuscular Intensity

    Time frame: Collected in two sessions: Session 1(day 1 for 2 hours) collected continuously during 2 exercise bouts to compare exercise bouts.____Session 2 (day 2 for 2 hours) collected continuously in four exercise bouts to compare exercise bouts

    bicycling cadence collected continuously

  2. Physiological Responses to Exercise- Oxygen Consumption

    Time frame: Collected in two sessions: Session 1(day 1 for 2 hours) collected continuously during 2 exercise bouts to compare exercise bouts___ Session 2 (day 2 for 2 hours) collected continuously in four exercise bouts to compare exercise bouts

    Metabolic equivalents derived from oxygen consumption which is collected continuously during four exercise bouts.

  3. Enjoyment-Motivation

    Time frame: Collected in two sessions: Session 1 collected continuously during 2 exercise bouts in a 2 hour Session 2: in four exercise bouts in a 2 hour session to compare exercise bouts

    Intrinsic Motivation Inventory Enjoyment sub-scales collected at the end of each exercise bout

  4. Heart Rate % of maximum

    Time frame: Collected in two sessions: Session 1 collected continuously during 2 exercise bouts in a 2 hour Session 2: in four exercise bouts in a 2 hour session to compare exercise bouts

    Collected continuously during exercise bouts and will be evaluated as a % of age adjusted maximum heart rate

Secondary outcomes

  1. Borg Scale for Rate of perceived exertion

    Time frame: Collected in both Day 1 and 2 (each day is two hours) as follows: Day 1 (4 times in each of the two cycling bouts) Day 2 (6 times each of the four cycling bouts)

    Self-Report of Effort collected at a multiple time points to compare with exercise bouts

  2. Cyber sickness Questionnaire

    Time frame: Collected in Day 1 (2 hour session) twice to compare before and after scores

    16 item questionnaire about feelings or symptoms of cyber sickness

  3. Perceived Effort Ranking

    Time frame: Collected in once in day 1 and once in day 2

    Rating of Bicycling Conditions relative to each other (and audio recording of experience)

  4. Enjoyment Ranking

    Time frame: Collected in once in day 1 and once in day 2

    Rating of Bicycling Conditions relative to each other (and audio recording of experience)

Other outcomes

  1. UPDRS-III Subscale

    Time frame: Collected once in Day 1

    Description of Motor Performance Scored from 0-108 a lower score is better outcome

  2. Physical Activity Scale for the Elderly

    Time frame: Collected once in Day 1

    Exercise Inventory Questionnaire

  3. Geriatric Depression Scale (short form)

    Time frame: Collected once during Day 0 (screening)

    15 item inventory to rate depression (scored from 0-15 with a lower score being better)

Study contacts

Contact information is provided by the study sponsor or research team.

Judith Deutsch, PT, PhD

CONTACT

[email protected]

973-972-2373

Sharon McFarlane

CONTACT

[email protected]

9739720281

Sponsors and collaborators

Lead sponsor

Rutgers, The State University of New Jersey

Other

Collaborators

  • National Institute on Aging (NIA)
  • New York Institute of Technology

Registry information

Official study title

Virtual Cycling Environments (VCYCLE) Increases Exercise Intensity of Persons With Parkinson Disease

Acronym: VCYCLE_PD

Important dates

Study start
2021
Primary completion
2026
Study completion
2027
First posted
Mar 18, 2021
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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