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NCT Number: NCT07599449

Virological Surveillance of Acute Respiratory Infection in Primary Health Care in Metropolitan France

Every year in the fall and winter, numerous respiratory viruses (such as influenza viruses, SARS-CoV-2 (COVID-19), RSV, rhinovirus, and metapneumovirus) circulate in mainland France, causing acute respiratory infections (ARIs). These viruses can cause epidemics of varying severity, requiring close monitoring to determine their circulation levels and adapt public health measures accordingly. In France, ARI surveillance relies on two networks: the Sentinelles network in primary care and the RENAL network in hospitals. The Sentinelles surveillance is conducted in collaboration with Santé publique France, the National Reference Center for Respiratory Infection Viruses (Institut Pasteur and Hospices Civils de Lyon), and the University of Corsica. As part of the virological surveillance of ARIs, Sentinelles physicians are asked to collect nasopharyngeal swabs or saliva samples from a sample of patients presenting with an ARI during their clinic visits. This surveillance makes it possible to identify respiratory viruses circulating in primary care (general practice and pediatrics), to describe confirmed cases for each of the circulating viruses, and to estimate the impact of each on general practice. This surveillance also allows for the evaluation of the effectiveness of vaccines against influenza and COVID-19.

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Key information

Conditions

Respiratory Tract Infections (RTI) COVID - 19 COVID-19 Coronaviridae Infections Coronavirus Infections Infections Influenza Influenza -Like Illness Influenza, Human Lung Diseases Metapneumovirus Infection Mononegavirales Infections Nidovirales Infections Orthomyxoviridae Infections Paramyxoviridae Infections Pneumonia Pneumonia, Viral Pneumovirus Infections RNA Virus Infections RSV Infections Respiratory Syncytial Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Rhinovirus Infection Virus Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

IPLESP - UMR S 1136, N° BC 2908, Faculté de médecine Sorbonne Université, site Saint Antoine, 27 rue Chaligny

Paris, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

be seen by a general practitioner or pediatrician participating in the Sentinelles surveillance program;
between week 40 (late September-early October) and week 15 (mid-April) of each year
have an acute respiratory infection (ARI) as defined below: Sudden onset of fever (or feeling of fever) and respiratory symptoms
have given oral consent to participate in this monitoring or, in the case of minors, oral consent given by the child's legal guardian(s) present at the consultation

Exclusion criteria

a person who is subject to a court-ordered protective measure;
a person who is under guardianship or conservatorship, unless accompanied by their legal guardian or unless the legal guardian objects to their participation;
a person who is not in a condition to receive information or give consent.

Treatment and study plan

saliva sampling

Diagnostic Test

Based on the protocol, physicians perform either a nasopharyngeal swab or saliva collection on included patients. The method is determined by scientific data and epidemiological constraints, not by the patient.

Saliva collection:

The physician oversees the collection during the visit using the provided kit (pipette, tube, etc.).

Depending on constraints, the patient may perform the collection at home if agreed upon.

If the patient is unable to self-collect (e.g., infants, facial paralysis), the physician collects the saliva directly from under the tongue using the pipette.

Nasopharyngeal swab

Diagnostic Test

Nasopharyngeal sampling: During the consultation, the physician performs a deep nasal swab using the provided kit (FFP2 mask, swab, transport tube, absorbent, SafetyBag, and pre-paid envelope for partner labs).

Primary outcomes

Proportion of acute respiratory infection (ARI) cases seen in private practice (general practice and pediatrics) that tested positive for influenza viruses (by type and subtype), SARS-CoV-2, RSV, rhinovirus, and metapneumovirus

Time frame: Baseline

Secondary outcomes

Weekly incidence rate of acute respiratory infections caused by influenza viruses and SARS-CoV-2 seen in general practice

Time frame: Baseline
Proportion of patients included vaccinated against influenza

Time frame: Baseline

Study contacts

Contact information is provided by the study sponsor or research team.

Olivier STEICHEN, MD, PhD

CONTACT

[email protected]

Thierry BLANCHON, MD, PhD

CONTACT

[email protected]

+33664846662

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Acronym: RS-viro IRA

Important dates

Study start: 2026
Primary completion: 2031
Study completion: 2031
First posted: May 20, 2026
Registry last updated: Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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