Video Game-based Physical Activity Training in People With Multiple Sclerosis During Relapse Treatment

Number of people referred from physician and eligible for screening. Number of people attending interview with researcher.

Barriers (screening interview). Burden (reasons for not taking part/discontinuation or dropping out).

Number of sessions attended.

Qualitative interview (end of program).

The Timed 25-Foot Walk is a quantitative mobility and leg function performance test. The patient is directed to one end of a clearly marked 25-foot course and is instructed to walk 25 feet as quickly and safely as possible. The time is calculated from the initiation of the instruction to start and ends when the patient has reached the 25-foot mark. The task is immediately administered again by having the patient walk back the same distance. Patients may use assistive devices when doing this task. The score is the average time of the two completed trials. Higher time represents slower walking speed and more walking impairment.

The 12-Item Multiple Sclerosis Walking Scale is a patient-reported outcome measure that assesses the impact of multiple sclerosis on walking. It consists of 12 questions with Likert-type choose options concerning the limitations to walking due to multiple sclerosis during the past 2 weeks. The total score ranges 0 from 100. Higher scores indicate more impact of multiple sclerosis on walking.

The Modified Fatigue Impact Scale provides an assessment of the effects of fatigue in terms of physical, cognitive, and psychosocial functioning. The scale consists of 21 items with Likert-type choose options. The total score for the scale is the sum of the scores for the 21 items. Individual subscale scores for physical, cognitive, and psychosocial functioning can also be generated by calculating the sum of specific sets of items. The total score ranges from 0 to 84. A higher score indicates higher level of fatigue.

The 2-Minute Walk Test is a submaximal exercise test that entails measurement of distance walked over a span of 2 minutes. The goal is for the individual to walk as far and fast as possible in 2 minutes. The total distance is recorded. Higher distance represents a better submaximal exercise capacity.

Six-Spot Step Test reflects a complex array of sensorimotor functions, part of which are lower limb strength, spasticity, and coordination, as well as balance. The score is the average time of the four completed trials. Higher time represents more walking impairment.

The Nine-Hole Peg Test is used to assess manual dexterity performance. It requires participants to repeatedly place and then remove nine pegs into nine holes, one at a time, as quickly as possible. Two trials for each hand are performed and the score is the average time. Higher scores indicate less manual dexterity performance.

The Manual Ability Measurement-36 is a questionnaire on perceived ease or difficulty that a persons may experience when performing unilateral and bilateral activity of daily living tasks. During a semi-structured interview, the persons are asked to rate 36 unilateral and bilateral activity of daily living tasks using a 4-point scale. The score of the different tasks are summed up and transformed using a Rasch-derived conversion table. The Rasch-derived scores are ranged from 0 to 100. Higher scores indicate better manual ability.

The Epworth Sleepiness Scale is a self-administered questionnaire with 8 questions. Respondents are asked to rate, on a 4-point scale (0-3), their usual chances of dozing off or falling asleep while engaged in eight different activities. The score (the sum of 8 item scores, 0-3) can range from 0 to 24. The higher the score, the higher that person's average sleep propensity in daily life, or their 'daytime sleepiness'.

The Multiple Sclerosis International Quality of Life Questionnaire is a disease-specific, self-administered, multidimensional questionnaire, was co-developed and initially validated in 15 countries including Turkey. The questionnaire comprises 31 questions in 9 subscales: activities of daily living, psychological well-being, symptoms, relationships with friends, relationships with family, sentimental and sexual life, coping, rejection, and relationships with the healthcare system. All 9 dimensions and the index score were linearly transformed and standardized on a 0-100 scale, where 0 indicates the worst possible level of quality of life and 100 indicates the best level.

The scale aims to measure symptoms of generalized anxiety disorder and consists of 7 items. Each item is scored on a response-scale with four alternatives ranging between 0 and 3. Higher scores indicate higher symptoms.

The scale aims to measure symptoms of depression and consists of 7 items, seven items. Each item is scored on a response-scale with four alternatives ranging between 0 and 3. Higher scores indicate higher symptoms.

The Symbol Digit Modalities Test is used to assess information processing speed. Using a reference key, the test taker has 90 seconds to pair specific numbers with given geometric figures in the Symbol Digit Modalities Test. The correct matches are calculated as the test score. Higher scores indicate better information processing speed.

The California Verbal Learning Test-II is used to assess verbal memory. Higher scores indicate better verbal memory.

The Revised Brief Visuospatial Memory Test is used to assess visuospatial memory. Higher scores indicate better visuospatial memory.

The Paced Auditory Serial Addition Test is used to assess auditory information processing speed and flexibility, as well as calculation ability. The score for the Paced Auditory Serial Addition Test is the total number correct out of 60 possible answers. Higher scores indicate higher cognitive function.