Vibration Response Imaging (VRI) in Lung Transplant Recipients

• Study participants will be patients who have undergone lung transplantation during the last 6 months and are in a stable clinical position at the time of enrollment.
• Patients who meet the study inclusion and exclusion criteria will be enrolled in the study.
• The enrolled patients will be recorded with the VRI at each occurrence in which the standard procedures are performed:

• Baseline after study enrollment (VRI Recording 1 + standard evaluations).
• At each follow-up visit [1, 3, 6 months after baseline visit] during the 6 month follow-up period of the study (VRI Recordings + standard evaluations (if possible)).
• In the event of bronchoscopic intervention, then before the interventional procedure (VRI Recording 1 + standard evaluations) and before any recurrent interventional procedures (VRI Recordings + standard evaluations) during the course of the study (6-month follow-up period).
• 1 hour after all bronchoscopic interventional procedures.
• In the event of an unanticipated visit, then a VRI recording will be performed (VRI Recordings + standard evaluations).
• All subjects will be recorded according to a standard procedure; moreover, it is essential that for each subject repeatable recordings will be performed in the same manner (i.e. breathing manner and matrix placement). Each VRI recording session will take ~15 minutes [the actual recording is ~2 minutes for placement and breathing/recording].
• Standard evaluation procedures may include any of the following:

• Lung function tests (this test is required at all visits)
• Physical examination
• Bronchoscopy (e.g. transbronchial biopsy)
• CT-imaging
• Chest x-ray
• V/Q Scan (Baseline visit for single lung transplantation)
• Blood gases (this test is required at all visits)
• Blood tests

Inclusion criteria

Subjects must meet all of the following inclusion criteria to be entered into the study:

• Able and willing to read, understand, and provide written Informed Consent
• Male or Female in the age range of 18-65 years
• Subject is a lung transplant recipient who underwent single or double lung transplantation within the last 6 months
• BMI > 19
• Height of >1.55 meters
• Stable clinical condition at study baseline evaluation

Exclusion criteria

Any of the following will exclude the subject from study:

• Intubated patients
• Chest wall deformation
• Spine deformation (including severe scoliosis)
• Hirsutism
• Potentially contagious skin lesion on the back
• Skin lesion that would interfere with sensor placement
• Cardiac pacemaker or implantable defibrillator
• Patient is pregnant as confirmed with urine pregnancy test
• Colonization of multi-resistant bacteria (MRSA) If the subject meets all of the inclusion criteria and none of the exclusion criteria, he/she is eligible to participate in the study.