Vibration Response Imaging in Chronic Obstructive Pulmonary Disease and Asthma

Obstructive lung disease is usually a differential diagnostic consideration when a patient presents with breathlessness or cough. Spirometry is the key diagnostic test used to confirm airflow obstruction particularly in the primary care setting. Airflow obstruction that completely resolves after administration of a bronchodilator, by definition, excludes a diagnosis of COPD. Evaluation of obstructive lung disease must include pulmonary function testing; bronchoreversibility testing is an adjunct in differentiating between asthma and COPD. Bronchoreversibility cannot serve as an absolute diagnostic criterion for separating asthma from COPD.

Vibration response imaging (VRI) technology provides a simple, radiation-free method to image the lungs, by visualizing vibration energy (lung sounds) emitted during respiration cycle. In this study, regional quantitative and qualitative information on vibration response is compared with spirometry in assessing lungs function of COPD and Asthma patients.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Airway Obstruction Asthma Bronchial Diseases Chronic Disease Disease Attributes Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiration Disorders Respiratory Hypersensitivity Respiratory Insufficiency Respiratory Sounds Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Baylor College of Medicine

Houston, Texas, 77030, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Able and willing to read, understand, and provide written Informed Consent
Male or Female in the age range of 18-85 years
Patients referred for evaluation of known or suspected obstructive airways disease.
Subject is referred for pulmonary function testing with pre-and post- bronchodilator
BMI > 21
Patients who are treated with Bronchodilators should go through a washout period prior the VRI procedure according to the Pulmonary Function Laboratory protocol.
Stable clinical condition at study baseline evaluation.

Exclusion criteria

Chest wall deformation
Spine deformation (including severe scoliosis)
Hirsutism
Potentially contagious skin lesion on the back
Skin lesion that would interfere with sensor placement
Pregnant or lactating females.

Treatment and study plan

Primary outcomes

The primary study objective is evaluation of the VRI qualitative and quantitative assessment before and after spirometry with bronchodilators.

Time frame: One day

Secondary outcomes

The secondary objective is correlating the VRI evaluations with lung function test results

Time frame: One day

Sponsors and collaborators

Lead sponsor

Deep Breeze

Industry

Registry information

Official study title

Evaluation of Vibration Response Imaging (VRI) in Chronic Obstructive Pulmonary Disease and Asthma Patients Before and After Bronchodilators

Important dates

Study start: 2006
Study completion: 2007
First posted: Oct 11, 2007
Registry last updated: Jun 16, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed