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Completed

NCT Number: NCT03424551

Vibration Induced Reflex Responses and Estimation of TVR

The aim of this study is to estimate tonic vibration latency and whole body vibration reflex latency

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Key information

Conditions

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Istanbul, Turkey (Türkiye)

About this study

This study was included 17 patients with spastic spinal cord lesions and 23 healthy control.

Soleus T-reflex, soleus H-reflex, soleus tonic vibration reflex (TVR), and reflex muscle response induced by whole body vibration was evaluated this study. To obtain the H-reflex response, the tibial nerve in the popliteal region was stimulated by using a stimulator (FE155 Stimulator HC ADInstrument, Oxford UK) with 1 ms-pulse current. The records was taken with the Ag / AgCl electrodes (Kendall ®Coviden, self-adhesive electrodes) placed on skin according to the SENIAM protocol. To obtain T-reflex response, an electronic reflex hammer (Elcon 100-150 Germany) was used. After H-reflex and T reflex records at rest, to obtain Tonic vibration reflex, local vibration was applied to the Achilles tendon at 50, 85, 140, 185, 235 and 265 Hz. To obtain the reflex response induced by Whole body vibration, vibration was applied at 35, 37, 39, 41, 43 and 45 Hz. Tibial nerve stimulation was performed again to determine Hmax during whole body vibration and local vibration.H-reflex records was taken while the subject is sitting on a chair.

The data was recorded with the PowerLab data acquisition device (ADInstrument Oxford UK). For Whole-body vibration, PowerPlate Pro5 (London UK) was used.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

spinal cord injury patients:

  • Spastic spinal cord lesion
  • Patients between the ages of 20 and 45

Exclusion criteria

for spinal cord injury patients

  • Accompanying trauma
  • Lower extremity fracture
  • Lower extremity peripheral nerve lesions
  • Head trauma
  • Autonomic dysreflexia
  • Heterotopic ossification
  • Lesions in calf skin
  • Excessive spasticity (Ashwort4) / Contracture (knee, hip, footbath)
  • Peripheral nerve-vascular diseases / muscle diseases
  • Pressure ulcer (> Grade 2)

Inclusion criteria

for Control

  • Ages 20 and 45 old years
  • Both sex
  • Healthy volunteers

Exclusion criteria

for Control

  • Pregnant women

Treatment and study plan

Vibrator

Device

Local or whole body vibration was applied at six different frequencies

Other names: cyclic mechanical loading

Primary outcomes

  1. Presynaptic inhibition level

    Time frame: 1 day

    Change in Hmax amplitude during vibration

Sponsors and collaborators

Lead sponsor

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Other Gov

Registry information

Official study title

Vibration-induced Reflex Responses and Estimation of Tonic Vibration Latency

Acronym: VIRR&TVR

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Feb 7, 2018
Registry last updated
Aug 20, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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