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NCT Number: NCT07177820

VGAIT for Chemotherapy-induced Peripheral Neuropathy

Perform a feasibility study on imagined acupuncture treatment of Chemotherapy-induced peripheral neuropathy (CIPN)

Recruiting

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Key information

Age range

18 year–80 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Charlestown, Massachusetts, 02129, United States

Location status: Recruiting

Location contact

Sierra Hodges, B.S.

CONTACT

[email protected]

617-726-5004

About this study

We will perform a pilot study to assess the feasibility of Video-Guided Acupuncture Imagery Treatment (VGAIT) on CIPN symptoms in patients with stage I-III breast cancer with persistent CIPN after adjuvant chemotherapy. Participants will receive 16 sessions of VGAIT over 8 weeks remotely through the zoom. Study measures will be collected at the time of study enrollment, week 4, and week 8. The primary endpoints of the study will be 1) retention to treatment; 2) satisfaction for the intervention and 3) completion of study assessments.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 18 years of age
  • have histologically confirmed stage I-III breast cancer,
  • have completed adjuvant taxane-based chemotherapy (alone or in combination), ,
  • have an Eastern Cooperative Oncology Group performance status of 0 or 1, and reported grade 1 or greater CIPN symptoms for more than 2 weeks as defined by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE), version 4.03.

Exclusion criteria

  • concurrent chemotherapy (there were no limitations on time from the last paclitaxel administration),
  • having metastatic or recurrent disease,
  • history of preexisting peripheral neuropathy prior to chemotherapy,
  • uncontrolled seizure disorder,
  • unstable cardiac disease or myocardial infarction within 6 months prior to study entry, being pregnant or nursing, or having used acupuncture for CIPN within 6 months prior to study entry.

Treatment and study plan

video-guided acupuncture imagery treatment (VGAIT)

Other

Participants watch a video of acupuncture being applied to the body while simultaneously imagining that it is being administered to them

Primary outcomes

  1. Feasibility related outcomes

    Time frame: 8 week

    Completion, satisfaction

Secondary outcomes

  1. Patient Neurotoxicity Questionnaire (PNQ)

    Time frame: baseline, 8 week

    A tool designed to assess neurotoxic effects in patients who have undergone treatments such as chemotherapy

  2. Functional Assessment of Cancer Therapy-Neurotoxicity subscale (FACT-NTX)

    Time frame: baseline, 8 week

    a widely used, validated instrument that assesses the impact of neuropathy on health-related quality of life

  3. Brief Pain Inventory-short form (BPI-SF)

    Time frame: baseline, 8 week

    An instrument used to evaluate the severity of pain, including neuropathic pain, and the impact on the patient's daily functioning.

  4. European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (QLQ-C30) instrument

    Time frame: baseline, 8 week

    an instrument developed to assess the quality of life in cancer patients

  5. MGH Acupuncture Sensation Scale (MASS)

    Time frame: after each intervention

    scale includes 12 descriptors of sensations frequently described during acupuncture treatment

  6. Pain Catastrophizing Scale (PCS)

    Time frame: baseline, 8 week

    a 13-item self-report scale which measures pain-related rumination, magnification, and helplessness

Study contacts

Contact information is provided by the study sponsor or research team.

Jian Kong

CONTACT

[email protected]

16179620978

Sierra Hodges

CONTACT

[email protected]

6177265004

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Official study title

Video-Guided Acupuncture Imagery Treatment in Chemotherapy-induced Peripheral Neuropathy

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 17, 2025
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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