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Completed

NCT Number: NCT05786144

Vestibular Schwannoma Organoids

In standard of care regularly planned surgery, tissue will be obtained from patients who are suspicious for having vestibular Schwannoma (on MRI). The tissue that remains after the pathologist gathered sufficient for analysis, the remaining tissue is used for creating tumour stem cell organoids.

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Key information

Conditions

Vestibular Schwannoma Cranial Nerve Diseases Cranial Nerve Neoplasms Ear Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue Nerve Sheath Neoplasms Nervous System Diseases Nervous System Neoplasms Neurilemmoma Neuroectodermal Tumors Neuroendocrine Tumors Neuroma Neuroma, Acoustic Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Peripheral Nervous System Neoplasms Retrocochlear Diseases Vestibulocochlear Nerve Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Maastricht University Medical Center, Maastricht, Limburg, Netherlands

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About this study

This project constitutes scientific research since the presence of tumor stem cells has not been shown in schwannoma before. Secondly the organoid model has not yet been described for VSs. The correlation between effect in schwannoma organoids and in patients has to be evaluated but can proof to be very valuable since it has been shown in a number of tumors. The tumor tissue will be acquired during regularly planned surgery. The tissue that is used is what is left after sufficient material has been sent to the pathologist to make the diagnosis. So the tissue that is used is removed routinely during surgery, but instead of banking it at the pathology department, it is used for the research project. Blood samples that can be used to compare normal DNA to tumor cells DNA will be acquired from central lines that are routinely placed during these procedures, so no additional interventions will be done in acquiring the tissue and blood for this study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • MRI with suspicion for vestibular schwannoma
  • Indication for surgery in the skull base committee
  • 18 years or older

Exclusion criteria

  • Refusal to participate
  • Younger than 18 years
  • Incapacitated

Treatment and study plan

Primary outcomes

  1. Feasibility

    Time frame: 10 years

    Feasibility to create organoids from schwannoma tumour tissue and make a "living" biobank of these tissues in the laboratory to study the resistance mechanisms towards treatments.

Secondary outcomes

  1. Phenotype

    Time frame: 10 years

    Comparing the phenotypical profile of the vestibular schwannoma organoid to the phenotypical profile of the original tumour.

  2. Genetic

    Time frame: 10 years

    Comparing the genetic profile of the vestibular schwannoma organoid to the genetic profile of the original tumour.

  3. Epigenetic

    Time frame: 10 years

    Comparing the epigenetic profile of the vestibular schwannoma organoid to the epigenetic profile of the original tumour.

  4. Proteomic

    Time frame: 10 years

    Comparing the proteomic profile of the vestibular schwannoma organoid to the proteomic profile of the original tumour.

  5. Transcriptomic

    Time frame: 10 years

    Comparing the transcriptomic profile of the vestibular schwannoma organoid to the transcriptomic profile of the original tumour.

Sponsors and collaborators

Lead sponsor

Maastricht Radiation Oncology

Other

Collaborators

  • Maastricht University Medical Center

Registry information

Official study title

Vestibular Schwannoma Stem Cell Organoids

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Mar 27, 2023
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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