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Completed

NCT Number: NCT02212704

Verticality Perception - Multisensory Contribution

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

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Key information

Conditions

Verticality Perception in Healthy Human Subjects Behavior Individual Contribution of Different Sensory Systems Orientation, Spatial Spatial Behavior

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Zurich, Dept. of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ages 18-60 years
  • informed consent
  • absence of exclusion criteria

Exclusion criteria

  • peripheral-vestibular deficit
  • disturbed consciousness
  • history of sensory deficits
  • visual field deficits
  • other neurological or systemic disorder which can cause dementia or cognitive dysfunction
  • intake of antidepressants, sedatives, or neuroleptics
  • pregnancy, unless excluded by a negative pregnancy test
  • known neck pain or status post neck trauma

Treatment and study plan

Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)

Other

3D-video-head impulse testing

Other

Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study

Vestibular-evoked myogenic potentials (VEMPs)

Other

Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study

Primary outcomes

  1. Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions

    Time frame: During the turntable measurement (90 minutes)

Secondary outcomes

  1. relative contribution of head- and trunk-based sensory systems based on Bayesian modelling

    Time frame: while on the turntable (1.5 hours)

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Verticality Perception - Dissociating Head and Trunk Contributors in Healthy Human Subjects

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Aug 8, 2014
Registry last updated
Nov 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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