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NCT Number: NCT07565259

Verbal Breathing Coaching to Improve Preoxygenation and Extend Safe Apnea Time in Anesthesia

This study explores whether simply guiding patients to breathe slowly and calmly before anesthesia can help improve oxygen levels and keep them safe for longer during induction.

The investigators included 120 participants scheduled for elective surgery, comparing routine preoxygenation with a gentle, coached breathing technique using steady inhalation and exhalation.

The investigator focused mainly on how long participants could safely tolerate apnea, while also examining oxygen levels, vital signs, and anxiety.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Prince Sultan Military Medical City

Riyadh, Saudi Arabia

About this study

This study looks at a simple but meaningful question: can the way the investigators talk to participants-and guide their breathing-make anesthesia safer? Before induction, participants are usually asked to breathe oxygen through a mask, but many do so in a shallow or irregular way due to anxiety or lack of guidance. Here, the investigators introduce a calm, structured approach where participants are gently coached to take slow, deep breaths with controlled inhalation and prolonged exhalation, helping them feel more relaxed and engaged in their own care.

the investigators included 120 adult participants scheduled for elective surgery, all relatively healthy (ASA I-II), and divided them into two groups. One group received the usual instructions to "breathe normally," while the other group was guided step-by-step with simple verbal cues to regulate their breathing pattern. This small change transforms a passive process into an active, patient-centered interaction, potentially improving how effectively oxygen fills the lungs before anesthesia.

the investigators main focus is on "safe apnea time"-how long a patient can maintain adequate oxygen levels after induction before desaturation begins. the investigators also look at additional factors such as oxygen concentration at the end of preoxygenation, changes in blood pressure and heart rate, and even how anxious the participant feels before going to sleep. These measures help the investigators understand not only the physiological benefits but also the emotional impact of this approach.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Scheduled for elective surgery under general anesthesia with tracheal intubation.
  • BMI < 35 kg/m²
  • The Ability to understand and follow verbal instructions

Exclusion criteria

  • Patients with an anticipated difficult airway
  • Significant cardiopulmonary disease
  • Pregnancy
  • Emergency surgery
  • Pre-existing hypoxemia (SpO₂ < 94% on room air)
  • Use of sedative premedication affects respiratory drive.

Treatment and study plan

Verbal Breathing Coaching

Procedure

In addition to standard preoxygenation, patients receive continuous verbal coaching:

"Breathe in slowly through your nose for four seconds" "Now breathe out slowly through your mouth for six seconds" Instructions repeated rhythmically for 3 minutes Delivered by the attending anesthesiologist using a standardized script

Primary outcomes

  1. Oxygen saturation

    Time frame: 3 minutes

    time from loss of consciousness to SpO₂ reaching 92%

Secondary outcomes

  1. End-tidal Oxygen concentration

    Time frame: 3 minutes

    the percentage of oxygen measured in the last portion of exhaled breath at the end of expiration.

  2. Mean arterial pressure

    Time frame: 3 minutes

    Mean arterial pressure

  3. Heart rate

    Time frame: 3 minutes

    Heart rate

Sponsors and collaborators

Lead sponsor

Prince Sultan Military Medical City

Other

Registry information

Official study title

Structured Verbal Breathing Coaching During Preoxygenation Prolongs Safe Apnea Time During Induction of General Anesthesia: a Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 4, 2026
Registry last updated
May 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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