Ventricular Reversed Remodeling After LTX in PAH Patients

In this study, pre-LTX and six-months post-LTX measurements will be compared with each other and between the primary and control group.

Pre- and post-LTX measurements include:

Past medical history: Including basic diagnosis; interventions, surgery and transplant related complications (re-operations, hospitalizations, infections) and medication history; These data will be collected by studying the medical files including surgical reports.

Present medical history: Including NYHA class.

Physical examination: Including length and weight.

Cardiac Magnetic Resonance Imaging:

• Ventricular volume, function and mass measurements
• Flow measurements of the pulmonary artery and aorta
• Disease specific measurements (e.g. septal bowing, RV trabecularisation, etc.)
• T1-mapping

Transthoracic Echocardiography

Resting ECG: Disease specific electrophysiological findings (e.g. QRS-duration, right bundle branch block).

Laboratory evaluation:

• NT-pro-BNP
• eGFR
• Remaining serum will be stored.

Inclusion criteria

• Patients who are on the waiting list for double-LTX, in our institution, for pulmonary arterial hypertension.
• Eligible for CMR imaging
• No claustrophobia
• No pacemaker, ICD, etc.
• Informed consent

Exclusion criteria

• Inability to comply with primary endpoint measures.
• Body mass index ≥40 kg/m2.
• Pregnant patients will not be included, they may be included >3 months after pregnancy.
• Patients with age <18 years.