Ventilator Mode and Respiratory Physiology

Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.

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Key information

Conditions

Pulmonary Disease Breathing Mechanics Lung Diseases Respiration Disorders Respiratory Effort Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California San Diego Health

La Jolla, California, 92037, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Admitted to ICU with acute respiratory failure
On adaptive pressure control mode of ventilation
Tidal volumes set between 5-8 cc/kg ideal body weight

Exclusion criteria

Current use of neuromuscular blockade
Inability to obtain consent from patient or surrogate decision maker
Treating clinician refusal

Treatment and study plan

lung mechanics, respiratory drive and effort

Other

Patient lung mechanics and respiratory drive and effort will be measured

Primary outcomes

Excess tidal volume

Time frame: From enrollment to end of monitoring at 4 hours

Exhaled tidal volume greater than 2cc/kg ideal body weight above intended or set tidal volume

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2029
Study completion: 2029
First posted: Oct 2, 2024
Registry last updated: Oct 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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