Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants

To non-invasively estimate the alveolar surface area of the lungs of prematurely born infants by taking measurements of oxygen and carbon dioxide and utilizing functional morphometry.

Completed

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Key information

Conditions

Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities Infant, Newborn, Diseases Infant, Premature, Diseases Lung Diseases Lung Injury Respiratory Tract Diseases Ventilator-Induced Lung Injury

Age range

22 week–28 week

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

King's College Hospital NHS Foundation Trust

London, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Exclusion criteria

Congenital or chromosomal anomalies

Treatment and study plan

Calculation of ventilation-perfusion ratio

Other

Three to five paired measurements of fraction of inspired oxygen and peripheral oxygen saturations.

Insertion of mainstream capnograph with combined pressure and flow sensor to perform end-tidal capnography measurement.

Echocardiogram to assess intra-cardiac shunting.

Primary outcomes

Calculation of the alveolar surface area in prematurely born infants using validated functional morphometry

Time frame: One year

Sponsors and collaborators

Lead sponsor

King's College London

Other

Collaborators

King's College Hospital NHS Trust

Registry information

Official study title

Functional Morphometry and Ventilation Perfusion Ratio to Estimate the Alveolar Surface Area in Prematurely Born Infants

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2023
First posted: Jun 23, 2021
Registry last updated: Mar 17, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed