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NCT Number: NCT05816928

Ventilation-Perfusion Matching in Early-stage Prone Position Ventilation

Prone positioning has been widely used in critical care medicine to improve oxygenation in patients with acute respiratory distress syndrome (ARDS). This study aimed to compare the effect of pronation on lung ventilation-perfusion matching between COVID19-associated acute respiratory distress syndrome (CARDS) and ARDS from other etiologies (non-CARDS) using electrical impedance tomography (EIT).

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Key information

Conditions

Acute Respiratory Distress Syndrome COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

PUMC

Beijing, Beijing Municipality, 100730, China

About this study

In this prospective study, both COVID19-associated ARDS (CARDS) patients and patients with ARDS from other etiologies (non-CARDS) were enrolled. Electrical impedance tomography (EIT) was used to evaluate the changes in ventilation and perfusion between supine and prone positions. Baseline values of the area of DeadSpace, shunt, ventilation-perfusion matching (VQmatch) were identified at the time of enrollment. Within the defined VQmatch region, the global inhomogeneity index (VQmatch-GI) was calculated to assess the degree of uniformity within the region. Prone position was applied immediately after the baseline data were collected. After 2 hours of proning, another EIT examination was conducted. Parameters such as DeadSpace, shunt, VQmatch, and other common measurements before and after pronation were taken and compared to evaluate the effect of prone positioning on CARDS and non-CARDS patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Above the age of 18
  • Diagnosed with ARDS based on the Berlin Definition of ARDS
  • Under mechanical ventilation

Exclusion criteria

  • Contraindications to EIT examination and prone position
  • Refusal of signing the informed consent

Treatment and study plan

Primary outcomes

  1. DeadSpace

    Time frame: 3 months

    The area of Deadspace will be assessed using electrical impedance tomography

  2. Shunt

    Time frame: 3 months

    Shunt will be assessed using electrical impedance tomography

  3. Ventilation-perfusion matching (VQmatch)

    Time frame: 3 months

    VQmatch will be assessed using electrical impedance tomography

  4. Global inhomogeneity index (VQmatch-GI)

    Time frame: 3 months

    Within the defined VQmatch region assessed by electrical impedance tomography, the global inhomogeneity index (VQmatch-GI) was calculated to assess the degree of uniformity within the region.

Secondary outcomes

  1. Ventilation

    Time frame: 3 months

    The ventilation of the lungs is assessed by electrical impedance tomography before and after prone positioning.

  2. Perfusion

    Time frame: 3 months

    The perfusion of the lungs is assessed by electrical impedance tomography before and after prone positioning.

  3. Center of Ventilation (CoV)

    Time frame: 3 months

    The center of ventilation of the lungs is assessed by electrical impedance tomography before and after prone positioning.

  4. Standard deviation of regional ventilation delay

    Time frame: 3 months

    The standard deviation of regional ventilation delay of the lungs is assessed by electrical impedance tomography before and after prone positioning.

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

Ventilation-Perfusion Matching in Early-stage Prone Position Ventilation: A Comparison Between COVID-19 ARDS and ARDS From Other Etiologies

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Apr 18, 2023
Registry last updated
Apr 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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