Control
OtherA standardized diet without any vegetables was provided.
Completed
NCT Number: NCT03483558
Vegetable Signature From Human Metabolomics Responses
The purpose of this study is to perform dietary intervention studies on a variety of vegetables.
Completed
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Notify MeKey information
Age range
18 year–60 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
About this study
Plant-based foods have always been an important component of a healthy diet. High intake of plant foods may not only maintain normal bodily functions through the provision of dietary fiber, vitamins, and minerals but also relieve symptoms and prevent diseases. Many studies have pointed out that high intake of plant foods may reduce the incidence of non-communicable disease. Past research investigating the effect of phytochemicals has usually been limited to single substances or single foods. However, a number of researchers have pointed out that phytonutrients and dietary components are likely to act synergistically.Health effects and mechanisms of phytonutrients in combination have not been carefully studied in population settings. The technology of metabolomics has enabled the simultaneous measurement of hundreds of small molecules in biological samples. Exploring the change of metabolites after feeding can not only help us understand the role of plant foods, but may also provide opportunities to assess plant food intake levels.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- BMI 18.5~30 kg/m2
- non-smoker
- non-alcoholic
Exclusion criteria
- Unwilling to stop taking the dietary supplements that may affect the experiment result.
- Unwilling to take the provided meal during the designated period.
- Taking hypertension or diabetes drugs.
- Diagnosed immune diseases (such as allergic diseases, autoimmune diseases, etc.), liver diseases, metabolic diseases (such as hyperthyroidism or hypothyroidism), or other not suitable for the dietary study.
- Diagnosed cancer or other severe diseases.
- Suffered from urinary tract infection or took antibiotic in the past three months
Treatment and study plan
Spinach
OtherA standardized diet with 200g spinach was provided.
Celery
OtherA standardized diet with 200g celery was provided.
Onion
OtherA standardized diet with 200g onion was provided.
Mixed Vegetables
OtherA standardized diet with 200g of mixed vegetables (spinach, celery, and onion) was provided.
Primary outcomes
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Intensities of multiple serum metabolites
Time frame: Baseline (fasting state before breakfast at 7:30AM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 4 Hours (immediately before lunch at 11:30AM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 5.5 hours (after lunch at 13:00PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 6.5 hours (after lunch at 14:00 PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 7.5 hours (after lunch at 15:00PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 8.5 hours (after lunch at 16:00PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 9.5 hours (after lunch at 17:00PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 10.5 hours (after lunch at 18:00PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple serum metabolites
Time frame: 11.5 hours (after lunch at 19:00PM)
The outcome measure consists of intensities of multiple serum metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple urinary metabolites
Time frame: Baseline (overnight urine sample collected at 7:30AM)
The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple urinary metabolites
Time frame: 3.5~4 hours (before lunch urine sample collected during 11:00~11:30AM)
The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple urinary metabolites
Time frame: 4.5~6.5 hours (2-hour after lunch urine sample collected from 12:00 to 14:00PM)
The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple urinary metabolites
Time frame: 6.5~8.5 hours (4-hour after lunch urine sample collected from 14:00 to 16:00PM)
The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
-
Intensities of multiple urinary metabolites
Time frame: 8.5~11.5 hours (7-hour after lunch urine sample collected from 16:00 to 19:00PM)
The outcome measure consists of intensities of multiple urinary metabolites from a liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) experiment. Intensity means the level of response variable (a given metabolite) showing the degree of response detected by LC/TOF/MS.
Sponsors and collaborators
Lead sponsor
National Health Research Institutes, Taiwan
Other
Collaborators
- Academia Sinica, Taiwan
- Fu Jen Catholic University
- Tri-Service General Hospital (TSGH)
Registry information
Official study title
Dietary Intervention Studies on a Variety of Vegetables
Important dates
- Study start
- 2011
- Primary completion
- 2012
- Study completion
- 2015
- First posted
- Mar 30, 2018
- Registry last updated
- Mar 30, 2018
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.