VDR SNPs & 25OHD Correlated With Dyslipidemia

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

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Key information

Conditions

Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Single Nucleotide Polymorphism

Age range

20 year–81 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Shenzhen Center for Chronic Disease Control

Shenzhen, Guangdong, 518020, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1) ≥ 20 years old Han Chinese;
2) living in Shenzhen for > 2 years;
3) free of liver diseases, renal diseases, and any cancers in the past 6 months; and
4) not in pregnancy for women.

Exclusion criteria

1) had severe organic diseases,
2) had acute infection symptoms, allergic diseases, and malignant tumors,
3) had a family history of genetic diseases,
4) took VD supplements in the past 6 months,
5) took medicines to control lipid levels within 12 hours, or
6) took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Treatment and study plan

No intervention.

Other

No intervention.

Primary outcomes

SNPs of VDR

Time frame: 6 months

Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1
lipid profiles

Time frame: 6 months

Serum concentrations of TG, TC, LDLC, and HDLC
25OHD

Time frame: 6 months

Plasma 25-hydroxyvitamin D concentration

Sponsors and collaborators

Lead sponsor

Shenzhen Center for Chronic Disease Control

Other

Collaborators

Sun Yat-sen University

Registry information

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2016
First posted: Jan 13, 2021
Registry last updated: Jan 13, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed