Skip to main content
OpenTrials
Completed

NCT Number: NCT04124718

VDR and TFIP11 Gene Polymorphism and Gene-environmental Interaction in Adults

VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Low Caries Experience High Caries Experience

Age range

24 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Recep Tayyip Erdogan University Dentistry Faculty

Rize, 53000, Turkey (Türkiye)

About this study

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

TFIP11 and VDR genes are related to enamel formation genes

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult be between 24 and 40 years old
  • subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT>13.9

Exclusion criteria

  • systemic or genetic disorders
  • orthodontic appliances
  • pregnant women

Treatment and study plan

high caries experience

Genetic

DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit

Other names: DNA isolation, genotyping

Primary outcomes

  1. past caries experience

    Time frame: 3 weeks

    Each tooth will be examined and recorded as decayed, missing, or filled

Secondary outcomes

  1. Plaque index

    Time frame: 3 weeks

    The plaque amount is scored by using Silness&Löe Plaque Index plaque index PI<1.0 healthy PI 1.1-2.0 mild PI>2 high plaque

Sponsors and collaborators

Lead sponsor

Recep Tayyip Erdogan University Training and Research Hospital

Other

Registry information

Official study title

Association Between Enamel Gene Variants and Dental Caries in Adults

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Oct 11, 2019
Registry last updated
Apr 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.