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Completed

NCT Number: NCT07345520

VCMX, PRF and SCTG Treatment in the Gingival Recessions

Comparison of Volume-Stable Collagen Matrix, Platelet-Rich Fibrin, and Subepithelial Connective Tissue Graft in the Treatment of Multiple Adjacent Gingival Recessions: A Parallel-Group, Randomized, Controlled Clinical Trial

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Key information

Conditions

Gingival Recession, Localized Gingival Diseases Gingival Recession Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Ankara Yıldırım Beyazit University

Ankara, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

were as follows:

  • ≥2 mm buccal recessions affecting ≥2 adjacent maxillary teeth;
  • systemically and periodontally healthy;
  • non-smokers;
  • Miller Class I-II (no interproximal attachment or CEJ loss);
  • probing depth (PD) <3 mm;
  • GT ≥1 mm;
  • KGW ≥2 mm;
  • identifiable CEJ;
  • full-mouth plaque index (PI) <20%(O'Leary et al., 1972) and gingival index (GI) score of 0(Löe, 1967) and
  • vital teeth to be treated.

Exclusion criteria

included:

  • smokers;
  • caries/restorations/abrasions in the treated area, furcation involvement;
  • contraindications to surgery;
  • pregnancy or lactation;
  • medications compromising healing;
  • surgery in the same region within 2 years;
  • bleeding disorders;
  • requirement for antibiotic prophylaxis; and
  • collagen allergy.

Treatment and study plan

Volume-Stable Collagen Matrix

Biological

Volume-Stable Collagen Matrix

Primary outcomes

  1. Percentage of Complete Root Coverage

    Time frame: 12 Months

    Percentage of CRC will be calculated as: (number of teeth achieving complete root coverage) ÷ (total treated teeth)] × 100

Secondary outcomes

  1. Percentage of Mean Root Coverage

    Time frame: 12 months

    Percentage of root coverage will be calculated as: Percentage of root coverage: [(preoperative recession depth - postoperative recession depth) ÷ preoperative recession depth] × 100

  2. Recession depth

    Time frame: 12 month

    RD will be measured from the cemento-enamel junction (CEJ) to the gingival margin and reported in millimeters (mm).

  3. Probing depth

    Time frame: 12 months

    Probing depth will be measured from the gingival margin to the base of the sulcus and reported in millimeters (mm).

  4. Clinical attachment level

    Time frame: 12 months

    Clinical attachment level will be measured from the cemento-enamel junction to the sulcus base and reported in millimeters (mm).

  5. Keratinized gingiva width

    Time frame: 12 months

    KGW will be measured from the mucogingival junction to the gingival margin and reported in millimeters (mm).

  6. Gingival Thickness

    Time frame: 12 months

    Gingival thickness (GT) will beevaluated at the mid-facial aspect, 2 mm apical to the gingival margin in the attached gingiva or alveolar mucosa, using a #15 endodontic spreader (Bahadır Diş, Istanbul, Turkey) with a rubber stopper under local anesthesia and reported in milimeters.

  7. Postoperative Pain assessed using a Visual Analog Scale (VAS)

    Time frame: From the day of surgery through postoperative day 10 (11 days)

    Postoperative pain will be assessed using a visual analog scale (VAS). Patients were asked to record the highest perceived pain each day from the day of surgery through the 10th postoperative day (total of 11 days).

  8. Dentin Hypersensitivity Score assessed using Air Stimulus (HSS)

    Time frame: Baseline, 6 months, and 12 months

    Dentin hypersensitivity will be assessed using a 1-second air stimulus applied to the buccal surface of the treated tooth. Patients rated the perceived hypersensitivity on a numerical rating scale ranging from 0 (no hypersensitivity) to 10 (unbearable hypersensitivity).

  9. Pink Esthetic Score (PES) self-assessment

    Time frame: Baseline, 6 months, and 12 months

    Esthetic outcomes will be evaluated using the Pink Esthetic Score (PES). Patients self-assessed gingival contour, gingival color, and overall esthetic appearance using a numerical rating scale ranging from 0 (unpleasant) to 10 (excellent).

  10. Postoperative Analgesic Consumption

    Time frame: From the day of surgery through postoperative day 10 (11 days)

    Postoperative analgesic consumption will be assessed by recording the total number of analgesic tablets taken by patients from the day of surgery through the 10th postoperative day.

Sponsors and collaborators

Lead sponsor

Bulent Ecevit University

Other

Registry information

Official study title

Comparison of Volume Stable Collagen Matrix, Platelet-Rich Fibrin and Connective Tissue Graft in the Treatment of Multiple Gingival Recessions: A Randomized, Parallel Group, Controlled Clinical Trial

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jan 15, 2026
Registry last updated
Jan 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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