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NCT Number: NCT00815269

Vasodilation Effect of Inhalational Anesthetics

Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.

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Key information

Conditions

General Anesthesia Aneurysm Cardiovascular Diseases Vascular Diseases

Age range

19 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nanjing Maternal and Child Health Care Hospital

Nanjing, Jiangsu, 210004, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Must be undergoing general anesthesia
  • Age between 19-45 years

Exclusion criteria

  • With hypertension
  • Existing organic dysfunction
  • Allergic to inhalant anesthetics
  • Alcohol addictive or narcotic dependent patients
  • A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records

Treatment and study plan

Halothane

Drug

Induction: 2-4% halothane pluses 3-5 L/min oxygen Maintenance: different doses from 0.5% to 3% with 1-2 L/min oxygen

Other names: Fluothane

Isoflurane

Drug

Induction: 2-5% isoflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen

Other names: Forane

Sevoflurane

Drug

Induction: 3-8% sevoflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen

Other names: Sevorane

Desflurane

Drug

Induction: 2-8% desflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen

Other names: Suprane

Enflurane

Drug

Induction: 2-5% enflurane pluses 3-5 L/min oxygen Maintenance: different doses from 1% to 4% with 1-2 L/min oxygen

Other names: Ethrane

Primary outcomes

  1. Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery

    Time frame: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia

Secondary outcomes

  1. Blood flow volume during anesthesia of the vasculature

    Time frame: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia

  2. Blood pressure including systolic, diastolic and mean artery blood pressures

    Time frame: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia

  3. The time interval of between the initiation of the inhalational anesthetics delivered to the beginning of decreasing of blood pressure

    Time frame: From the beginning of anesthesia (0 min) till the first time of blood pressure decreased, this measure would be varied according to different individuals

  4. The total dose of phenylephrine required to maintain baseline arterial blood pressure

    Time frame: From the beginning of anesthesia (0 min) to 20 min after anesthesia begun

  5. Regression and correlation analyses between different doses of the anesthetics and the extent of vasodilation

    Time frame: Forty eight hours after operation

Sponsors and collaborators

Lead sponsor

Nanjing Medical University

Other

Registry information

Official study title

Vasodilation Effect of Inhalational Anesthetics Including Halothane, Isoflurane, Sevoflurane, Desflurane and Enflurane

Acronym: VEFIHA

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Dec 29, 2008
Registry last updated
Dec 23, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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