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Completed

NCT Number: NCT02842593

Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

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Key information

Conditions

Weight-Lifting Exercise Program

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

McMaster University

Hamilton, Ontario, L8S4L8, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Aged 18-30 years old
  • Non-obese (Body mass index less than 30 kg/m2)
  • Non-smoker
  • Healthy based on questionnaire responses
  • Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion criteria

  • Allergies to milk proteins (whey or casein)
  • Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
  • Arthritic conditions
  • Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
  • A history of neuromuscular problems
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Treatment and study plan

Lower-repetition, heavier-load

Behavioral

8-12 reps/set at ~80% 1 repetition maximum

Higher-repetition, lighter-load

Behavioral

20-25 reps/set at ~30% 1 repetition maximum

Primary outcomes

  1. Carotid-femoral pulse wave velocity

    Time frame: 12 weeks post exercise training

    Assessed using applanation tonometry

Secondary outcomes

  1. Common carotid artery distensibility

    Time frame: 12 weeks post exercise training

    Assessed using vascular ultrasound

  2. Left ventricular mass

    Time frame: 12 weeks post exercise training

    Assessed using standard echocardiography

Sponsors and collaborators

Lead sponsor

McMaster University

Other

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jul 25, 2016
Registry last updated
Jan 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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