Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST

Erythromelalgy (EM) is a vascular syndrome very rare affecting the feet. This disease evolve by crisis when the feet extremities become red hot and painful. There are several types of EM but this study concern the adult primitive form. For a long time, the physiopathology was not described but now we know that there is a vascular form, with microcirculatory dysfunction and a neurologic form with small fibers neuropathy. The diagnostic of neurologic form is based on clinical evaluation (DN4 questionnaire, UENS scale...) and an electromyography. Thermotest, a medical device which measure the thermic sensitivity is used to quantify neuropathy. More recently Sudoscan, a device measuring cutaneous impedance to chloride ions detect small nervous fiber in diabetic patients with good correlation with Thermotest.

The purpose of this study is to analyze the vascular side and the neurologic side on patients consulting for Erythromelalgy.

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Key information

Conditions

Erythermalgia Cardiovascular Diseases Erythromelalgia Peripheral Vascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Groupe Hospitalier Paris Saint Joseph

Paris, Île-de-France Region, 75014, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Pain with burn feeling at hands and feet extremities
Crisis activated by the heat
Age > 18 years old

Exclusion criteria

Patients who had burn in extremities

Treatment and study plan

impedance measurement and pain evaluation

Other

Measurement of chlorine ions impedance by SUDOSCAN and pain due to temperature evaluation with THERMOTEST

Primary outcomes

Assessment of Chlorine ion production change

Time frame: Day1

patient will be measured the impedance of chlorinates ions by Sudoscan
Assessment of Temperature changing sensitivity

Time frame: Day1

Patients will be measured their sensitivity to temperature changing using the Thermotest

Sponsors and collaborators

Lead sponsor

Fondation Hôpital Saint-Joseph

Other

Registry information

Official study title

Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2019
First posted: Feb 7, 2017
Registry last updated: Apr 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed