Varicose Vein in Patients Under the Age of 40

Varicose veins are a result of valvular insufficiency and presented with twisted, enlarged veins. They not only cause cosmetic concerns but also lead to limb edema, skin pigmentation/lipodermatosclerosis, and even venous ulcers. This disease affects a large percentage of the population. Although there have been several researches on the risk factors for varicose veins and the outcomes of alternative therapies , there is currently limited data focusing on varicose veins in young patients. In this case-control study, we wanted to assess the risk factors for varicose veins in patients under the age of 40, as well as their long-term results of surgery.

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Key information

Conditions

Varicose Veins Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital, College of Medicine, Zhejiang University

Hangzhou, Zhejiang, 310000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

great saphenous varicose veins (GSVV) with saphenous vein reflux >0.5s.
lower extremity venography excluding iliac vein compression;
treated by great saphenous vein stripping and ambulatory phlebectomy.
the patient had a minimum follow-up of five years.

Exclusion criteria

secondary varicose veins (defined as varicose veins caused by deep vein thrombosis, iliac venous compression or venous injury etc.);
small saphenous veins;
treated by endovenous ablation/laser or sclerotherapy alone.

Treatment and study plan

Great saphenous vein stripping and ambulatory phlebectomy

Procedure

All patients included in the study were treated with great saphenous vein stripping and ambulatory phlebectomy.

Primary outcomes

Postoperative varicose veins sequelae

Time frame: Five years after surgery.

The sequelae of the varicose vein were assessed by Venous Clinical Severity Score (VCSS). The total score is 0~30. The higher scores mean a worse outcome.
Postoperative quality of life

Time frame: Five years after surgery.

Quality of life was assessed by the Aberdeen Varicose Vein Questionnaire (AVVQ). The total score is 1~100. The higher scores mean a worse outcome.

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital of Zhejiang University

Other

Registry information

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2024
First posted: Jun 8, 2022
Registry last updated: Sep 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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