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Completed

NCT Number: NCT02879084

Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis

This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.

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Key information

Conditions

Anterior Uveitis Eye Diseases Intermediate Uveitis Panuveitis Uveal Diseases Uveitis Uveitis, Anterior Uveitis, Intermediate

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement. CHU de Québec

Québec, G1S 4LB, Canada

About this study

Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years old or more
  • anterior uncomplicated uveitis or intermediate uncomplicated uveitis

Exclusion criteria

  • history of uveitis in the past, other than the actual uveitis
  • history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness
  • optic nerve or macular clinically apparent edema
  • history of glaucoma or other optic neuropathy
  • suspected or confirmed multiple sclerosis
  • ocular hypertension (intraocular pressure more than 22 mmHg)
  • reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT

Treatment and study plan

Primary outcomes

  1. Retinal Nerve Fiber Layer Thickness in anterior uveitis

    Time frame: At time 0

  2. Retinal Nerve Fiber Layer Thickness in intermediate uveitis

    Time frame: At time 0

  3. Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis

    Time frame: at 4 to 6 weeks

  4. Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis

    Time frame: at 4 months

Sponsors and collaborators

Lead sponsor

CHU de Quebec-Universite Laval

Other

Registry information

Important dates

Study start
2016
Primary completion
2020
Study completion
2020
First posted
Aug 25, 2016
Registry last updated
Jan 27, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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