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OpenTrials
Completed

NCT Number: NCT03519776

Variation of Progesterone in IVF Cycles

to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering.

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Key information

Conditions

Progesterone Resistance

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

IVI Middle East Fertilty Clinic

Abu Dhabi, United Arab Emirates

About this study

The impact of the progesterone level at the end of the follicular phase in stimulated IVF/ICSI cycles and its effect on the pregnancy rate and oocyte quality is controversial, which arises from conflicting results in retrospective studies and meta-analyses. This study is assumed to examine if a natural daytime variation in progesterone levels may explain parts of the inconsistent findings from studies reporting divergent results concerning this matter and will be carried out by several blood samples from the same patient during the day of ovulation triggering. If variation is present, the impact of variation on the developing oocyte and embryo quality will be estimated by embryo quality indicators.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients 18-45 years
  • BMI 18-35 kg/m2
  • Menstrual cycle length 24-35 days
  • Stimulation with rFSH or hMG

Exclusion criteria

  • None

Treatment and study plan

Progesterone variation

Diagnostic Test

The potential gain for medical caretakers and patients would be a certainty if the progesterone level is affected by variations during daytime

Primary outcomes

  1. The variation of serum progesterone around the ovulation triggering in IVF-cycles

    Time frame: 6-8 months

    the circadian secretion-pattern of progesterone during early follicular phase of normal cycling females

Sponsors and collaborators

Lead sponsor

ART Fertility Clinics LLC

Other

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
May 9, 2018
Registry last updated
Feb 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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