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NCT Number: NCT06060639

Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients

The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. The main questions it aims to answer are :

* is there a modification of echocardiographic parameters after red blood cell transfusion ? * which parameter is the most impacted by red blood cell transfusion ? Participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.

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Key information

Conditions

Anemia Age Problem Hematologic Diseases Hemic and Lymphatic Diseases Ultrasonography

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Nîmes

Nîmes, Gard, 30900, France

Location status: Recruiting

Location contact

Fabien Coisy, MD

PRINCIPAL_INVESTIGATOR

Laura Grau-Mercier, MD

SUB_INVESTIGATOR

fabien coisy, MD

CONTACT

[email protected]

+33612194369

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient needing red blood cell transfusion
  • consent
  • social protection

Exclusion criteria

  • fluid filing over 500 mL of crystalloids
  • transfusion in the last hour

Treatment and study plan

Transthoracic echocardiography

Diagnostic Test

E wave, A wave, e' and vdi measurement

Primary outcomes

  1. E/A ratio modification

    Time frame: Base line, just after and 15 minutes after red blood cell transfusion

    E/A ratio permits to estimate left ventricle pressure

Secondary outcomes

  1. E/e' ratio modification

    Time frame: Base line, just after and 15 minutes after red blood cell transfusion

    E/e' assesses left ventricle diastolic function

  2. E wave deceleration time

    Time frame: Base line, just after and 15 minutes after red blood cell transfusion

    E wave deceleration time is a reflect of left atrium pressures

  3. Velocity-time Integral (VTI) modification

    Time frame: Base line, just after and 15 minutes after red blood cell transfusion

    Aortic velocity-time integral is the reflect of cardiac output

  4. Lung score modification

    Time frame: Base line, just after and 15 minutes after red blood cell transfusion

    Lung score permits to asses if extravascular water is present in lungs

  5. New York Heart Association scale (NYHA) modification

    Time frame: baseline and 24 hour after red blood cells transfusion

    NYHA is a validated scale to asses patient dyspnea

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Acronym: Trans-US

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Sep 29, 2023
Registry last updated
Dec 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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