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NCT Number: NCT07413640

Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors

Microwave ablation is a minimally invasive technique whose planning relies on manufacturer tables derived from ex vivo models that do not account for patient or tumor-specific factors. In clinical practice, the actual ablation volume often differs from the planned volume due to liver characteristics, vascular proximity, and tumor biology.

This study aims to assess the variability between ablation small axis during percutaneous microwave ablation of liver lesions. The influence of patient-related (fibrosis, steatosis, portal flow) and tumor-related factors (location, histology, prior treatment) will be evaluated. Small axis and volume will be compared with volumes measured on immediate post-procedural CT and on CT/MRI at 6-12 weeks, accounting for expected tissue shrinkage.

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Key information

Conditions

Liver Neoplasm Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Site

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU Nancy

Vandœuvre-lès-Nancy, F54511, France

Location status: Recruiting

Location contact

Astrée LEMORE

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients
Treated with percutaneous hepatic microwave ablation under CT or ultrasound guidance
Adult treated for one or more liver lesions
Patients with available follow-up imaging

Exclusion criteria

Two treatment cycles on the same lesion during the same session.
Reoperation on the same lesion.
Planned volume not available (no manufacturer data, not specified in the surgical report).
No control imaging injected between 1 and 4 months post-procedure.
Final ablation volume not measurable (e.g., artifacts, no injection on MRI).
No definitive diagnosis of the nature of the tumor on imaging and no histology available.

Treatment and study plan

Primary outcomes

Small final ablation axis measured on the post-procedure imaging modality considered to be the most reliable.

Time frame: 12 weeks

The final short axis will preferably be measured (in mm) on MRI at 6-12 weeks. If inter-patient variability in volume shrinkage exceeds 5%, the modality with the lowest relative variability (usually the immediate CT scan) will be used as the reference for estimating the final volume.

Study contacts

Contact information is provided by the study sponsor or research team.

Astrée LEMORE, MD

CONTACT

[email protected]

33383157823

Valérie LAURENT, MD-PhD

CONTACT

[email protected]

33383157823

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Variability of Microwave Ablation Volume Based on Clinical, Radiological, Biological, and Tissue Factors : a Retrospective Study

Acronym: MICRO-VAR

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Feb 17, 2026
Registry last updated: Feb 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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