Skip to main content
OpenTrials
Recruiting

NCT Number: NCT05384158

Valuation in Depressed Mood, Anhedonia, and Anxiety

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Neurobehavioral Components of Reward and Loss Valuation Anhedonia Anxiety Disorders Behavior Behavioral Symptoms Depression Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

25 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fralin Biomedical Research Institute at Virginia Tech Carilion

Roanoke, Virginia, 24014, United States

Location status: Recruiting

Location contact

Pearl Chiu, PhD

CONTACT

[email protected]

540-526-2032

About this study

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion criteria

  • history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Treatment and study plan

Cognitive behavioral therapy

Behavioral

cognitive behavioral therapy

valuation with instruction

Behavioral

repeat laboratory sessions of computerized learning game

valuation without instruction

Behavioral

repeat laboratory sessions of computerized learning game

Primary outcomes

  1. change in proportion correct on the 'N-arm bandit learning task'

    Time frame: study entrance to study exit, an average of 12 weeks

    change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit

Secondary outcomes

  1. change in depression symptoms (Beck Depression Inventory)

    Time frame: study entrance to exit, an average of 12 weeks

    change in depression symptoms from study entrance to study exit

  2. change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)

    Time frame: study entrance to exit, an average of 12 weeks

    change in anxiety symptoms from study entrance to study exit

  3. change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)

    Time frame: study entrance to exit, an average of 12 weeks

    change in anhedonia symptoms from study entrance to study exit

Sponsors and collaborators

Lead sponsor

Virginia Polytechnic Institute and State University

Other

Registry information

Official study title

Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

Important dates

Study start
2021
Primary completion
2026
Study completion
2026
First posted
May 20, 2022
Registry last updated
Sep 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.