Validation of the French Version of the Primary Lateral Sclerosis Functioning Rating Scale (PLSFRS)

This is a national, multicentric, prospective, descriptive study evaluating the psychometric properties of the French version PLSFRS scale

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Lateral Sclerosis Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University hospital, Brest, France

About this study

This is a prospective study conducted in 8 French ALS centers which will enroll 80 patients with PLS. All these patients will undergo an evaluation of their functional status from the ALSFRS-r and PLSFRS scales. All patients will be evaluated at 3 time points (T0,M6 at the outpatient clinic) and at M3 remotely. The aim of the study will be to validate a trans-cultural and psychometric version of the PLSFRS available for the French PLS population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with primary lateral sclerosis (PLS)
Age over 18 years
Informed consent signed
Patients cared in a French ALS centre

Exclusion criteria

patients with no oral and written command of the French language
Patients unable to answer a questionnaire
Opposition to data processing

Treatment and study plan

Assessment of the functional status

Other

assessment of their functional status using the French version of the PLSFRS scale during a routine multidisciplinary assessment every 3-6 months for all patients with motor neurone disease, as recommended by the FILSLAN network

Primary outcomes

French version of the PLSFRS scale

Time frame: inclusion and 6 months

10 items with a score from 0 to 6; 2 items with a score from 0 to 4 Maximal score is 68.

Secondary outcomes

Change Global Impression (CGI) scale

Time frame: 6 months

overall clinical impression of the change; score from 1 to 7

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Registry information

Official study title

Validation of the French Version of the PLSFRS Scale

Acronym: FRENPRILS

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Mar 14, 2025
Registry last updated: May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed