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NCT Number: NCT06485960

Validation of the Experience Sampling Dietary Assessment Method

A new dietary assessment method was developed based on the Experience Sampling Methodology. In order to use this newly developed Experience Sampling Dietary Assessment Method (ESDAM) in research and clinical practice as a valid and reliable method to measure dietary intake the ESDAM needs to be validated against objective biomarkers and reference methods.

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Key information

Conditions

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

The purpose of this research project is to advance nutritional research by delivering an improved, accurate, feasible and reliable method to assess dietary intake. Our newly developed approach to collate dietary intake based on experience sampling methodology (ESM) will serve this purpose.

Therefore, this research aims to validate the newly developed Experience Sampling Dietary Assessment Method (ESDAM) by assessing construct validity compared to blood and urine biomarkers representing dietary intake. This will eventually result in the newly developed dietary assessment method being evidence-based and validated and, thus, ready-to-use as a reliable method for research and clinical practice.

Therefore, the ESDAM will be validated against repeated 24-hour dietary recalls, the doubly-labelled water method, urinary nitrogen and blood biomarkers. The study has a duration of four weeks. The first two weeks will be used to collect baseline data including socio-demographic, biometric data and three 24-hour recalls to assess dietary intake. During the last two weeks the Experience Sampling Dietary Assessment Method will be evaluated against urine biomarkers (Doubly-labeled water and urinary nitrogen), blood biomarkers (erythrocyte membrane fatty acid composition, beta-carotenoids, polyphenols) together with continuous glucose monitoring and two wrist-worn motion sensor devices to track eating- related movements.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Signed informed consent
  • Having a smartphone and being capable of using the smartphone and apps
  • Having a freezer at home
  • Sufficient knowledge of the Dutch language to understand and participate in the study
  • Having a stable body weight (body weight not changed by 5% last 3 months)
  • Not aiming to gain or lose weight during the study period

Exclusion criteria

  • Pregnant or lactating women
  • Not following a specific diet for medical reasons (i.e. coeliac disease)

Treatment and study plan

ESDAM validation

Other
  • 3* 24-Hour Dietary Recalls
  • Experience Sampling Dietary Assessment Method (mobile application)
  • Continuous Blood Glucose Monitoring
  • Wrist- worn motion sensors
  • Doubly-labeled water administration
  • Blood drawings (Erythrocyte Membrane Fatty Acid composition, Carotenoids, polyphenols)
  • Urine sampling (Doubly-labeled water, urinary nitrogen)

Primary outcomes

  1. Daily dietary energy intake based on the Experience Sampling Dietary Assessment Method

    Time frame: 2 weeks

    Daily dietary energy intake estimated by the Experience Sampling Dietary Assessment Method (ESDAM) compared to the Doubly-labeled Water Method

  2. Daily dietary protein intake based on the Experience Sampling Dietary Assessment Method

    Time frame: 2 weeks

    Daily dietary protein intake estimated by the Experience Sampling Dietary Assessment Method (ESDAM) compared to urinary nitrogen

  3. Daily energy expenditure derived from the doubly-labeled water method

    Time frame: 2 weeks

    Daily energy expenditure (kcal/day) measured by the doubly-labeled water method

  4. Daily dietary protein intake based on urinary nitrogen analysis

    Time frame: 2 weeks

    Daily dietary protein intake based on urinary nitrogen analysis

Secondary outcomes

  1. Dietary intake based on Experience Sampling Dietary Assessment Method

    Time frame: 2 weeks

    Daily nutrient and food group consumption estimated by the Experience Sampling Dietary Assessment Method ESDAM

  2. Dietary intake based on 24-hour dietary recalls

    Time frame: 2 weeks

    Energy, nutrient and food group consumption measured by the 24-hour dietary recalls

  3. Serum Beta-carotenoid concentration

    Time frame: 4 weeks

    Serum Beta-carotenoids as biomarker of fruit and vegetable consumption

  4. Erythrocyte membrane fatty acid composition

    Time frame: 4 weeks

    Erythrocyte membrane fatty acid composition as biomarker of fatty acid consumption

  5. Plasma polyphenol concentration

    Time frame: 4 weeks

    Plasma polyphenol concentration as an indication of dietary polyohenol intake

Other outcomes

  1. Timing of glucose peaks

    Time frame: 2 weeks

    Timing of glucose peaks registered by Continuous Glucose Monitoring

  2. Timing of eating-related motion

    Time frame: 2 weeks

    Timing of eating-related motion monitored by wrist-worn motion sensors

Study contacts

Contact information is provided by the study sponsor or research team.

Christophe Matthys, PhD

CONTACT

[email protected]

+32 16 34 26 55

Sponsors and collaborators

Lead sponsor

KU Leuven

Other

Registry information

Official study title

Validation of the Experience Sampling Dietary Assessment Method (ESDAM)

Acronym: YONAS

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 3, 2024
Registry last updated
Dec 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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