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OpenTrials
Completed

NCT Number: NCT05156567

Validation of a Multitask Deep Learning System at Spine Metastasis CT

15 resident oncologists were conducted to evaluate the clinical efficacy of DLS in multicenter. They were 1:1 randomly asked to independently read the test images without the assistance of DLS software or with the assistance. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the DLS were calculated with professional graders as the reference standard.

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Key information

Conditions

To Evaluate Performance of the DLS

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai Sixth People's Hospital

Shanghai, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pathology-proven diagnosis of solid tumor;
  • spinal CT scan indicating spinal metastasis with at least one lesion;
  • no previous surgery for spinal metastasis

Exclusion criteria

  • spinal CT scans with no sagittal reconstruction;
  • the radiologist considered that the quality of CT image was unqualified.

Treatment and study plan

Deep Learning System

Diagnostic Test

The multitask DLS with five algorithms detecting spine metastases and evaluate features (bone lesion quality, posterolateral involvement, and vertebral body collapse)

Primary outcomes

  1. AUC

    Time frame: 1 months

    Area under the receiver operating characteristic curve (AUC) of spinal instability detection

Secondary outcomes

  1. sensitivity

    Time frame: 1 months

    sensitivity of spinal instability detection

  2. specificity

    Time frame: 1 months

    specificity of spinal instability detection

Sponsors and collaborators

Lead sponsor

Shanghai 6th People's Hospital

Other

Registry information

Official study title

Multicenter Validation of a Multitask Deep Learning System for Spine Metastases Detection Andfeatures Evaluations at Spine Metastasis CT

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Dec 14, 2021
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.