Validation and Implementation of 3T MRI Research Protocols

This is a prospective monocentric research on major participants (healthy and patients). The optimization of the sequences will be carried out in an incremental way from one control to the other: for each control, several sequences will be carried out for an acquisition time not exceeding one hour of cumulated acquisition (i.e. one hour and a half including the installation and the delays between the sequences). Each sequence lasts between 5 and 20 minutes.

At the end of the examination, the images obtained will be evaluated jointly by an expert neuroradiologist and a research engineer specialized in image analysis according to the criteria mentioned above. This analysis will make it possible to determine the parameters to be modified to improve image quality and to define the acquisition parameters for the next test.

As soon as a sequence is considered optimal, it will be tested on a small number of healthy controls (≈ 5) to ensure interindividual reproducibility of image quality parameters, and then if necessary in the presence of pathology in a few patients (≈ 5).

Inclusion criteria

• Male or female, 18 years of age or older
• Ability to cooperate and remain motionless for up to 1 hour (and lying down for 1.5 hours)
• Ability to understand the instructions given
• Subject who has given written and informed consent prior to any examination required by the research)
• Subject affiliated to a social security system or benefiting from an equivalent system

Exclusion criteria

• Persons deprived of liberty by judicial or administrative decision
• Psychiatric disorders, disorders of cognitive functions, not allowing the realization of the MRI
• Protected adults (subject to a measure of legal protection) or unable to express their consent
• Subject with Contraindications to MRI