Skip to main content
OpenTrials
Completed

NCT Number: NCT04730752

Validation and Comparison of the Appendicitis Inflammatory Response Score and Adult Appendicitis Score

Acute appendicitis is one of the most frequent reasons of emergency laparotomy in adults. Symptoms of acute appendicitis overlap with other clinical conditions and might present as a challenge, especially in the early phases. Despite the advances and widespread use of imaging modalities, still negative laparotomies are performed with the initial diagnosis of acute appendicitis. Several scoring systems are developed by using various clinical and laboratory parameters in order to improve the diagnostic accuracy and prevent unnecessary laparotomies.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Acute Appendicitis Acute Appendicitis With Rupture Appendicitis Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Niğde Ömer Halisdemir University Training and Research Hospital

Niğde, 51100, Turkey (Türkiye)

About this study

In the recent guideline of World Society of Emergency Surgeons (WSES) recommendations regarding the clinical scoring systems for acute appendicitis are remarkable. It is stated that clinical scoring systems, on their own, can be used to exclude acute appendicitis and decrease negative laparotomy rates. Currently Appendicitis Inflammatory Response Score (AIR) and Adult Appendicitis Score (AAS) are the best clinically performing scoring systems. As a result, based on strong evidence the use of these two systems are recommended. Both scoring systems are developed on the basis of clinical findings and laboratory parameters.

The aim of this study is to validate both systems as well as to compare the efficiency of both systems on excluding negative laparotomies and on the determination of severity of acute appendicitis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presenting to ER with right lower quadrant pain
  • Patients between 18-65 years old.

Exclusion criteria

  • Patients receiving immun-suppressive therapy
  • Patients with diagnosed malignancy
  • Presence of mental retardation
  • Patients with previous right hemicolectomy
  • Patients with previous appendectomy
  • Pregnant women

Treatment and study plan

Appendicitis Inflammatory Response

Diagnostic Test

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Adult Appendicitis Score

Diagnostic Test

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Primary outcomes

  1. Exclude acute appendicitis

    Time frame: 6 months

    The ability of the scoring systems in detecting patients without acute appendicitis presenting with right lower quadrant pain to emergency service

  2. Predicting the severity of acute appendicitis

    Time frame: 6 months

    The ability of scoring systems in predicting the rate of perforation in patients with acute appendicitis

Sponsors and collaborators

Lead sponsor

Nigde Omer Halisdemir University

Other

Registry information

Official study title

Prospective Clinical Trial on Validation and Comparison of the Diagnostic and Prognostic Value of Appendicitis Inflammatory Response Score and Adult Appendicitis Score

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jan 29, 2021
Registry last updated
May 27, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.