Vaccination in the Peripheral Stem Cell Transplant Setting for Multiple Myeloma

The purpose of this study is to evaluate the safety and efficacy of vaccination with autologous myeloma cells and an allogeneic granulocyte-macrophage colony stimulating factor (GM-CSF) producing cell line.

Completed

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Key information

Conditions

Multiple Myeloma Blood Protein Disorders Cardiovascular Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Immune System Diseases Immunoproliferative Disorders Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Neoplasms, Plasma Cell Paraproteinemias Vascular Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Johns Hopkins University

Baltimore, Maryland, 21231, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

De novo multiple myeloma
ECOG 0-2
No serious co-morbid illnesses and adequate organ function
> 4 weeks from systemic steroids

Exclusion criteria

No existing secondary malignancies and no history of secondary malignancies in the past 5 years
No active autoimmune disease

Treatment and study plan

Therapeutic Cellular Vaccine, GM-CSF Producing

Biological

Primary outcomes

Multiple myeloma

Sponsors and collaborators

Lead sponsor

Cell Genesys

Industry

Registry information

Official study title

Vaccination in the Peripheral Stem Cell Transplant Setting for Multiple Myeloma: The Use of Autologous Tumor Cells With an Allogeneic GM-CSF Producing Cell Line

Important dates

Study start: 2000
Study completion: 2004
First posted: Jun 30, 2005
Registry last updated: Dec 24, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed