β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline

Inclusion criteria

• Cognitively unimpaired persons with SCD as well as individuals with MCI.
• To sign the study informed consent form, approved by the corresponding authorities.
• Participation (in-person at the institution or telephonically) of a relative to inform on the participant subjective memory decline and on the clinical interview*.
• Men and women between 55 and 80 years old
• Memory Alteration Test (M@T) ≤45
• Good knowledge of the either Spanish or Catalan language and being literate.

Exclusion criteria

• Presence of clinically relevant psychiatric disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) criteria: major depressive disorder, generalized anxiety disorder, schizophrenia and bipolar disorder, or any other condition that might impact cognition or performance on cognitive assessments as judged by the investigator
• Parkinson's disease, epilepsy in treatment and with frequent seizures (> 1 / month) in the last year, multiple sclerosis or other neurodegenerative disease.
• Contraindication to perform an MR scan: claustrophobia, pacemaker, metallic implants, etc.
• Contraindication to lumbar puncture
• Acquired brain injury: history of cranioencephalic trauma with gross parenchymal or extra axial lesion, hemorrhagic ischemic stroke, brain tumors and other aetiologies that can cause acquired brain damage (chemotherapy or brain radiotherapy).
• Investigator's criteria: Subjects that show any condition that, in the opinion of the investigator, could interfere in the proper execution of the study procedures and / or in their future permanence in the study.