Uveal Melanoma and Brachytheraphy: Long-term Outcomes.

This study investigated the visual and anatomical outcomes, tumor control, tumor recurrence, distant metastasis and cancer free survival in patients affected by uveal melanoma and undergoing Ru-106 plaque brachytherapy between February 2011 and March 2020

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Key information

Conditions

106 Ruthenium Plaque Brachytherapy Eye Diseases Eye Neoplasms Melanoma Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue Neuroectodermal Tumors Neuroendocrine Tumors Nevi and Melanomas Uveal Diseases Uveal Melanoma Uveal Neoplasms

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Naples "Federico II"

Naples, 80100, Italy

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age older than 40 years
diagnosis of uveal melanoma

Exclusion criteria

age older than 80 years
No diagnosis of uveal melanoma

Treatment and study plan

106 Ruthenium plaque brachytherapy

Radiation

All patients, affected by uveal melanoma, were treated with 106 Ruthenium plaque brachytherapy to a total dose of 100 Gy to the tumor apex. The time of implant duration was calculated according to the conventional central-axis-point dose calculation

Primary outcomes

To evaluate long-term outcomes in patients underwent brachytherapy for uveal melanoma

Time frame: Mean follow-up was 4 years (3 months-9 years)

To investigate the visual and anatomical outcomes, tumor control, tumor recurrence, distant metastasis and cancer free survival

Sponsors and collaborators

Lead sponsor

Federico II University

Other

Registry information

Official study title

Long-term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy

Important dates

Study start: 2011
Primary completion: 2020
Study completion: 2020
First posted: Oct 8, 2020
Registry last updated: Oct 8, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed