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Completed

NCT Number: NCT00818467

UVB Light and Sunscreen

Patients need vitamin D which is normally produced in the skin in response to ultraviolet light from the sun. Vitamin D is important for calcium absorption and good bone health. Physicians have been using sunscreens to protect patients from skin cancer and the aging effects of sunlight for a least a half a century. Dermatologists have promoted sunscreen use to restrict sunlight exposure especially in white Caucasians. If this behavior is done 100% of the time when outdoors individuals may suffer from vitamin D deficiency. It is impossible to influence persons' behavior to wear sunscreens all the time when outdoors. With the use of sunless tanning agent (DHA), once a week, we can obtain a continuous sunscreen in the top layer of the skin that will not wash off, can't be removed with soap and water, or removed by perspiration. Under these circumstances we can answer the scientific question, will sunscreen use inhibit the production of vitamin D in the skin?

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Key information

Conditions

Vitamin D Status

Age range

19 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Creighton University

Omaha, Nebraska, 68131, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • males or females
  • ages 19-50 with less than 16 oz milk per day
  • less than 10 hours of sun per week
  • no Vitamin D supplements
  • no anticonvulsants
  • no barbiturates
  • no steroids
  • no meds that increase photosensitivity
  • no granulomatous disease
  • no liver or kidney disease
  • no history of skin cancer
  • BMI less than 30
  • skin types I & II

Exclusion criteria

  • None

Treatment and study plan

Tanning spray

Other

using 3% DHA twice a week for the 1st week and then once a week for 4 weeks and receiving 40mJ UV-B phototherapy three times a week for four weeks

UVB

Other

receiving 40mJ UV-B phototherapy three times a week for four weeks

Primary outcomes

  1. To measure the response of 25(OH)D to 40 milliJoules of UV-B light in white Caucasians with melanoidins-sunscreen from 3% DHA in comparison to the response of control subjects who have not used 3% DHA.

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Creighton University

Other

Collaborators

  • The UV Foundation

Registry information

Official study title

3% Dihydroxyacetone (DHA or Sunless Tanning Agent) Inhibits Vitamin D Production in the Skin in Response to Ultraviolet Light

Acronym: Sunscreen

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Jan 7, 2009
Registry last updated
Dec 1, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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