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OpenTrials
Completed

NCT Number: NCT01217983

Utility of Renal Biomarkers in Cirrhosis

Evaluation of kidney function is critical in cirrhotic patients as there is a clear relationship between renal failure and prognosis. The investigators hypothesized that in this population new biomarkers of renal function could help in early detection of acute renal failure and in discrimination between renal and pre-renal causes. Finally the investigators hypothesized that such biomarkers could predict short-term outcome in this population.

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Key information

Conditions

Cirrhosis Ascitis Fibrosis Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital of Geneva

Geneva, 1211, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Known or suspected cirrhosis
  • Suspected ascitis
  • Informed consent signed

Exclusion criteria

  • Proven multifocal hepatocellular carcinoma
  • Acute gastric hemorrhage (active or < 2 weeks)
  • Known end-stage renal disease or on dialysis before admission
  • Recipients of kidney or liver transplants
  • Transferred from another institution

Treatment and study plan

Primary outcomes

  1. Early detection of acute kidney injury in hospitalized cirrhotic patients with ascitis using new renal biomarkers

    Time frame: 30 days

    Acute kidney injury will be defined using RIFLE and AKIN criteria.

Secondary outcomes

  1. Prediction of adverse clinical outcomes (Renal replacement therapy, transfer to ICU, all cause mortality).

    Time frame: 30 days

  2. Discrimination between different type of AKI.

    Time frame: 30 days

  3. Prediction of AKI developement using renal artery resistive indexes.

    Time frame: 30 days

Sponsors and collaborators

Lead sponsor

University Hospital, Geneva

Other

Registry information

Official study title

Utility of Renal Biomarkers in Cirrhotic Patients

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Oct 8, 2010
Registry last updated
Oct 30, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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