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NCT Number: NCT06001736

Utility of CC7 Transfer in Stroke Subtypes

The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.

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Key information

Conditions

Stroke, Ischemic Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Hemiplegia Hemorrhagic Stroke Ischemic Stroke Nervous System Diseases Neurologic Manifestations Paralysis Pathological Conditions, Signs and Symptoms Signs and Symptoms Spastic Hemiparesis Stroke Stroke Hemorrhagic Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dartmouth-Health

Lebanon, New Hampshire, 03677, United States

Location status: Recruiting

Location contact

Jennifer Hong, MD

PRINCIPAL_INVESTIGATOR

Lauren Sinks, MPH

CONTACT

[email protected]

603-653-9021

About this study

Spastic limb paresis after stroke is a cause of long-term disability and reduction is quality of life, with loss of hand dexterity being especially prohibitive. In the recovery phase after initial injury, neural reorganization occurs and has been observed in both ipsilateral and contralateral hemispheres. Previous studies have identified contralesional (opposite to the side of the injury), in other words, ipsilateral, activation in the recovery of paretic hand function. However, this pathway of recovery is limited due to sparse connections between the ipsilateral hemisphere and the affected arm/hand. By establishing an anatomic connection between the ipsilateral hemisphere and the paretic arm with contralateral nerve transfer, compensatory capacity of the ipsilateral hemisphere is facilitated. This cross neck C7-C7 root transfer is an established procedure for the treatment of brachial plexus injuries and recently, for the treatment of spastic arm paresis in those with cerebral injury.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.
  • baseline Fugl-Meyer score below 33

Exclusion criteria

  • pregnancy

Treatment and study plan

Contralateral C7 root transfer for the treatment of spastic hemiparesis.

Procedure

Performing surgery to transfer the C7 nerve to treat stroke patients experiencing spastic hemiparesis.

Primary outcomes

  1. Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale.

    Time frame: 12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery.

    The Fugl-Meyer is a widely used and highly recommended stroke-specific, performance-based measure of impairment with 5 domains and a possible 226 points.

Study contacts

Contact information is provided by the study sponsor or research team.

Lauren Sinks

CONTACT

[email protected]

(603) 653-9021

Sponsors and collaborators

Lead sponsor

Dartmouth-Hitchcock Medical Center

Other

Registry information

Official study title

Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Aug 21, 2023
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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