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OpenTrials
Completed

NCT Number: NCT01844362

Uterus Transplantation From Live Donor

Uterus transplantation, as a possible future treatment for uterine factor infertility, has been developed in animal species during the last decade.

The study protocol includes transplantation of the uterus from a live donor (mother, relative, friend) into women with absolute uterine factor infertility (lack of uterus from birth or due to life saving hysterectomy).The recipient will be treated by standard immunosuppression and transfer of embryos (acquired by IVF before surgery) will be attempted when at least 12 months have passed from transplantation. Approval for a case series including up to 10 patients has been acquired.

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Key information

Conditions

Primary Uterine Infertility Genital Diseases Infertility Urogenital Diseases

Age range

18 year–39 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Mats Brännström

Gothenburg, SE-41345, Sweden

About this study

The study is ongoing, with inclusion of 9 patients.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • less than 39 years
  • good general health

Exclusion criteria

  • poor ovarian resaerve or older than 39 years
  • systemic or psychiatric disease

Treatment and study plan

uterine transplantation

Procedure

Transplantation of the uterus from live donor and IVF treatment.

Primary outcomes

  1. surviving transplants (12 months)

    Time frame: up to 3 years after transplantation

Secondary outcomes

  1. pregnancy rate

    Time frame: up to 3 years after transplantation

Other outcomes

  1. live birth rate

    Time frame: up to 4 years after transplantation

Sponsors and collaborators

Lead sponsor

Sahlgrenska University Hospital

Other

Collaborators

  • The Swedish Research Council

Registry information

Official study title

Prospective Case Series of Human Uterus Transplantation From Live Donor

Acronym: utx

Important dates

Study start
2012
Primary completion
2018
Study completion
2021
First posted
May 1, 2013
Registry last updated
Jun 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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