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Completed

NCT Number: NCT04756661

Uterotonics for Severe Preeclampsia

The study compares the effect of Intravenous carbetocin versus combined use of intravenous oxytocin and rectal misoprostol for prevention of postpartum hemorrhage during delivery of women with severe preeclampsia

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Key information

Conditions

Preeclampsia Severe

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Assiut Faculty of Medicine

Asyut, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pregnant women which diagnosed with severe pre-eclampsia.
  • Singleton pregnancy.
  • Termination of pregnancy by Cesarean section after 28 weeks of gestation.

Exclusion criteria

  • Suspected or proven placental abruption.
  • Known placenta Previa or acreata.
  • Multiple pregnancies.
  • Obesity (BMI >35).
  • Anemia (<9 g/dl).
  • Retained placental tissues.
  • Big baby (> 4 kg).
  • Presence of coagulopathy.
  • Polyhydramnios.
  • Presence of Uterine fibroids.
  • Medical diseases as; cardiac, liver, renal or endocrine diseases.
  • General anesthesia.

Treatment and study plan

Carbetocin

Drug

100 mcg of Carbetocin intravenous injection

Oxytocin

Drug

10 IU oxytocin IV drip

Misoprostol

Drug

400 mcg rectal

Primary outcomes

  1. The rate of postpartum hemorrhage more than 1000 ml

    Time frame: 30 minutes

    the amount of bleeding during and after CS

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Carbetocin Versus Combined Oxytocin and Misoprostol for Prevention of Postpartum Hemorrhage in Women With Severe Preeclampsia

Important dates

Study start
2020
Primary completion
2020
Study completion
2021
First posted
Feb 16, 2021
Registry last updated
Feb 16, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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